Soccer Saturday pundit Charlie Nicholas is aiming for the £1m Super 6 jackpot and has shared his selections.
The six fixtures all kick-off at 3pm with Chelsea hosting Crystal Palace and Manchester United's clash with West Brom among the games on the menu.
Charlie is expecting Leicester's clash against Stoke to be one of a host of tight encounters as the Premier League returns after the international break.
"Leicester's clash against Stoke could make-or-break Soccer Saturday Super 6 players' chances of landing the £1m jackpot," Nicholas said.
"The Foxes seem to have turned the corner following Claudio Ranieri's departure, while Stoke can be fabulous one minute and awful the next - you just don't know what you are going to get.
"Most will be backing the hosts to win this but Stoke are awkward and will make it hard for Leicester.
"Mark Hughes could play the Foxes at their own game and let them have more of the ball and try and catch them out on the break, which could frustrate Leicester.
"I can see Marko Arnuatovic and Jamie Vardy both scoring, but I can't separate the two sides.
"I also expect the matches between Burnley and Tottenham, Hull and West Ham and Watford and Sunderland to all end in score draws. And I fancy both Chelsea and Manchester United to win at home."
Charlie's Super 6 predictions for the £1m round:
A £1m prize is available for picking six correct scorelines in the free-to-play Soccer Saturday Super 6 prediction game.
If the jackpot isn't won then the highest scoring player will receive £10,000.
Well over £1m has been paid out this season to players of the Soccer Saturday-backed game with a £250,000 top prize normally up for grabs.