Mark Harris' double helped push Oxford back into the League One play-off places as they ruthlessly beat Burton 4-0 at the Pirelli Stadium.
A long throw from Tom Hamer into the Oxford box was cleared and, when Tolaji Bola misjudged his header on halfway, Harris was able to race away, round keeper Max Crocombe and slot home midway through the first half.
The Welsh striker continued to torment the Brewers defence, adding a second early in the second half by bundling the ball in from eight yards out.
Josh Murphy grabbed a well-deserved goal shortly afterwards, driving from his own half to score on the counter-attack.
And, as Albion's defence capitulated, substitute James Henry added a fourth from inside the box, dispossessing Ryan Sweeney before firing into the bottom corner.
The margin of defeat pushed Albion into the bottom four on goal difference after Port Vale's point at Wigan.