National League leaders Lincoln City will travel to Arsenal for an historic FA Cup quarter-final.
Danny Cowley's side became the first non-league side in 103 years to reach the last eight of the competition by beating Premier League Burnley on Saturday.
And their reward is a quarter-final tie with 12-time winners Arsenal, who overcame another non-league side in Sutton United on Monday night.
Jose Mourinho will return to Stamford Bridge for a second time this season with holders Manchester United after they drew his former club Chelsea.
Tottenham will host a London rival in Millwall, who dumped Premier League champions Leicester out on Saturday.
Pep Guardiola's Manchester City, meanwhile, will travel to Middlesbrough if they can overcome Huddersfield in a replay at the Etihad Stadium on February 28.
All the last-eight ties will be played on the weekend of March 11 and 12, meaning a number of league fixtures will need to be rearranged.
Manchester United's Premier League trip to Southampton, Tottenham's game at Crystal Palace, Middlesbrough's derby with Sunderland and Chelsea's clash with Watford will be moved.
Millwall will need a different date to play Sheffield United and Lincoln's clash with Chester will also be moved.