Carlos Alcaraz will skip the ATP Finals and the Davis Cup Finals after picking up an abdominal injury at the Paris Masters, the world No 1 has confirmed.
Alcaraz is expected to be out for at least six weeks due to an "internal oblique muscle tear in the left abdominal wall", effectively ending his season.
"Unfortunately I won't make the ATP Finals or the Davis Cup Finals," he tweeted.
The Spaniard added: "It is tough and painful for me to miss these two events, which are so important to me, but all I can do is be positive and focus on my recovery. Thank you for the support!"
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Alcaraz retired from his last-eight match with Holger Rune after having treatment on an abdominal muscle, retiring during
his second-set tie-break against the Dane, who was 3-1 up and had won the first set 6-3.
The 19-year-old opted to quit the match in a bid to be fit for the November 13-20 ATP Finals but the injury has effectively ended his season.
He will not recover in time to represent Spain at the Davis Cup Finals from November 25-December 5 either.
Alcaraz completes his season with an impressive 57-13 record, while also becoming the youngest world No 1 in the history of the ATP Rankings.
He won five tour-level titles, including his first two ATP Masters 1000 victories in Miami and Madrid and his first Grand Slam trophy at the US Open.
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American Taylor Fritz, who is ninth in the ATP Race, is in line to take Alcaraz's spot at the season-ending ATP Finals in Turin