Last Updated: 20/12/14 5:22pm
James Wilson curls from 20 yards, but Guzan dives to his right to save well. And here come Villa! Bacuna puts a low cross in but it goes just too far ahead of N'Zogbia!
Unbelievably, it's Villa attacking. Sanchez's effort is deflected goalwards by Benteke, but De Gea collects.
Another priceless take from Guzan from Rooney's high corner. The American has been superb this afternoon, but will still have work to do as we approach the 90th minute.
Bacuna goes close! The substitute has some space 20 yards from goal, and his driven effort goes just wide of the upright. At the other end, Young's cross AGAIN finds Guzan.
Young, now on the right, puts in another cross, but Guzan collects. N'Zogbia is again offside at the other end after Phil Jones held a superb line.
Delph breaks clear and finds N'Zogbia running clear, but the Frenchman is offside. At the other end, Young's cross is too long for United's gathering attack.
Ryan Dougan (@RyanDougeDougan) says: 'Disaster for Villa, Gabby is a talisman and now he's out for the whole Christmas period.'
To Villa subs... Charles N'Zogbia and Leandro Bacuna come on to replace Andreas Weimann and Aly Cissokho.
Two corners are cleared by Okore as United pile on the pressure... and the third results in a Villa free-kick.
Whipped corner in from Rooney nearly creeps in, but Okore gets in the way of the ball on the line and clears for the corner. Villa fans are playing keep ball in the North Stand. Very, very petty stuff.
Mata spreads the ball wide to Di Maria, but his low cross is cleared by Okore. Carrick and Mata getting a bit more space to spray the ball into dangerous areas now.
Blackett catches Lowton this time, and Brad Guzan also picks up a yellow card for running 30 yards to Lee Mason to complain.
That's Agbonlahor's first red card in 362 career games - and Matt Le Tissier says it was harsh: 'It looked like it could have been a yellow to me. Lee Mason was very quick to get the red card out. I think he may have been a little bit harsh on Agbonlahor.'
Delph delivers a free-kick from the left, and it's pinball in the United area; Clark's effort is blocked by Evans, before Weimann's shot is deflected wide. De Gea claims the corner. That was a huge chance for Villa.
Villa fans are letting Young know what they think of him loud and clear, but their 10 men have a massive job on their hands to prevent United going ahead.
For the second week in a row Villa are down to 10 men. Agbonlahor goes in for a 50-50 with Young, misses the ball and catches his former team-mate. He could have got away with a yellow, but Lee Mason gives a red. Perhaps harsh... and now a long 25 minutes or so for Villa.
Carrick finds Di Maria in the area, but the Argentine takes it first time and fluffs the ball into Guzan's hands, before cutting inside a minute later and producing the same result.
Young attempts to keep the ball in as Lowton finally gets some attacking joy... it looks as though the ball went behind for a corner but the linesman gives a throw, and Villa's possession ends in an awkward shot for De Gea to deal with from Delph. The Spaniard collects, however.
United with all the possession now, and all the noise is from the away fans. Lowton fouls Young on the right and the visitors can threaten the box again. Second substitution by Van Gaal, Angel Di Maria is brought on for Robin van Persie.
I must say, Matt Lowton has done very little to snuff out Ashley Young's threat on the left wing. Young's delivery has been hit and miss, but Lowton has allowed him to put a ball in on every occasion, approaching double figures now.
Van Persie's overhead kick from 12 yards goes over, but United are fully in the ascendancy now. Villa sat back after their two chances after the break, and the goal was coming.
Well, well, well. Falcao finds himself in between Villa's centre-backs and heads home past Guzan from Young's superb cross from the left. The United fans go mad and they're right back in it. The pendulum has swung...
Guzan again gets down well to save from Juan Mata. The Spaniard has a yard on the corner of the box, but his drilled left-footed effort is blocked by the Villa stopper. Superb again.
Now a chance for United at the other end... Van Persie finds himself clear inside the penalty area one-on-one with Guzan, but the Dutchman's effort is saved well by the American. Great goalkeeping.
Two chances for Villa early on, both from the work of goalscorer Benteke. First, the big Belgian holds the ball up well and offloads to Delph, whose effort is cleared for a corner. The resulting corner falls to Benteke, rising high from eight yards out, but his powerful header is tipped over well by De Gea.
We're off for the second half here, and Van Gaal has made a change. Tyler Blackett is on for Darren Fletcher, and Carrick has moved into midfield for United.
Clark does superbly well to pressure Van Persie off the ball. A few weeks ago the Irishman was just an after thought, now he's on the form of his life after being allowed a way back into the first team because of injuries.
Rooney's delivery is cleared to Young, whose overambitious effort is high and wide into the Holte End Crowd who once sung his name.
More of the ball for Young on the left wing, and Lowton is really struggling contain the United man. Sanchez comes across to clear for a corner.
Villa keeping the ball but still doing nothing with it. The 'Oles' have come out from the Villa Park crowd. A bit premature, lads.
Good possession from Villa, mostly thanks to Benteke, who keeps the ball ticking over in United's half. Villa still uncertain in areas, particular when the ball is with their defence, but here they come on an attack...
Vlaar does well to clear at the byline, but looks to have picked up a little knock. He is looking to run it off but keeps holding his shin.
United come forward once more, but Guzan comes out to gather the cross again. More good goalkeeping from the ever-improving American.
Ashley Young's deep cross evades everyone apart from former team-mate Brad Guzan, who does well to get down and parry clear.
Villa attack through Agbonlahor and Sanchez, who finds Delph in the area... but the midfielder's attempt is blocked by Evans from 15 yards.
United with possession now as they attempt to force their way back into the game. The away fans have experienced plenty of comebacks here over the years... they'll need to produce another one to continue their run.
Rare possession for Villa as Cissokho somehow gets away from Valencia. His delivery is poor as it deflects of Rooney for a throw. But Villa retain the ball in midfield and settle down.
Rooney finds Valencia again with a brilliant ball... the Ecuadorian paces forward in typical fashion but his low driven cross is cleared by Clark for a corner. Mata's cross is met by Clark again as the attack dies down.
Chance for Falcao... Van Persie puts the Colombian in with only Okore for company, but the Danish defender does enough to squeeze Falcao out and his tame effort falls into the thankful hands of Guzan.
Fletcher puts in a poor cross well wide of Guzan's goal after Benteke gave the ball away for Villa. The hosts may have scored, but they don't look any more settled than before the goal.
Possession for United in the final third as Young twists Matthew Lowton inside-out, but the winger's cross is headed well wide by Valencia at the far post.
Rooney wins a free-kick in Villa's half as Vlaar stops the striker running through him. The set piece comes to nothing but Delph gives the ball away high up the pitch...
Villa Park erupts! The free-kick comes in deep, and Jonny Evans loses Benteke, who twists and turns 16 yards out... the Belgian curls through the masses of players in the area and into the corner of the net. Great goal.
Rooney finds Van Persie on the right angle of the penalty area, but his volley is saved by Guzan. Looked like a cross to Falcao, mind.
Bit of trouble in Villa's area. Three balls into the box are all cleared by the defence, two from Ashley Young, and Villa break... Benteke's lovely ball to Weimann evades the Austrian by just a yard.
United go from side to side but make progress up the field. Rooney plays a lovely diagonal to Valencia, but Villa once again snuff it out. Possession switching sides like ping pong at the moment
Cissokho is palmed off by Van Persie after the United man's poor touch from a throw. Villa battling their way into this...
Delph escapes a booking for coming in at the wrong side on Van Persie and tripping the Dutchman. Delph just about wins the ball but brings the United man down in the process.
Vlaar does superbly well to stop Falcao getting to a loose ball on the edge of the area, using his strength to get in front of the Colombian. Van Gaal will be watching... is this a January audition for the Dutchman?
Weimann's long ball forward is headed clear by Carrick and United look to build an attack. Fletcher and Mata exchange a few nice passes in the centre circle but Villa snuff out any threat.
Great footwork from Okore as Villa enter United's half... Agbonlahor has space approaching the penalty area and looks for Benteke with the short pass, but gives it straight to Michael Carrick. Poor from the striker.
Valencia does well on the wing, two against one, but his chipped cross falls into the arms of Guzan, luckily for Villa defender Aly Cissokho, who allowed the Ecuadorian to deliver.
Both sets of fans trying to make themselves heard on a brisk afternoon in the Midlands. United with plenty of possession but biding their time before attacking.
Villa struggling with possession as United begin to control the game already. The hosts are playing like the away side here...
Fletcher finds Mata in the middle of the park before the Spaniard spreads out wide to Young. He is booed, as always, by the Villa fans before whipping a ball across the area... Lowton misses the ball, but so does Van Persie. Early escape for the hosts.
Villa play around with it in their half and struggle to clear twice, once through Delph and then again through Okore. United have possession in Villa's half...
Ready for kick-off at a full Villa Park... United fans in full voice. Can Villa end this horrible run?
Despite having his own problems, Paul Lambert believes United can still win the title. 'They might not be able to lose many more games if they are going to win the title but they're certainly in with a shout,' he said. 'It is still a brilliant club with great players. The players they have brought in, there are not many teams in world football who can do that.'
Madison Lee (@OnikaMarajUK) says: 'I think if utd keep up the confidence and maybe bring in one defender in Jan, I don't see why we don't have a chance to win!'
Van Gaal insisted on Friday he wants his team playing better, despite Sir Alex Ferguson telling him it is all about results. The Dutchman said: 'He said: 'I'm not only focused on results, although of course that's the main thing. When I speak with Sir Alex he says: 'There's no problem - you've won'. But for me it's also the performance, because when you perform well you win more.'
Some strong words from former Villain Paul Merson before the game on Sky Sports News HQ: 'I think sooner or later they will get found out in a big way Man United. I don't see how they can cope with Christian Benteke. If Benteke plays well today I don't see how they can cope with him. I think he'll rip them to absolute shreds.'
Sky Bet make United odds-on at 4/7 to make it seven victories on the bounce, with their hosts 5/1 despite holding home advantage. Van Gaal's men have come in from 66/1 to 10/1 to win the Premier League thanks to their winning run, while they are now just 1/6 to be back in the Champions League next season.
Neal Newbrook (@NealNewbrook) says: 'a blitz at Villa with a 4 nil score line to the reds with Rooney to score 2, Van P with a late third and Di Maria to finish'
The talk of a United title challenge has crept into the airwaves recently after a long absence, and the busy Christmas period will be telling. Chelsea and Manchester City seem to be in a league of their own, but as we've all seen plenty of times before, when the United train starts it doesn't tend to stop. So, can they win it? Let me know your thoughts by tweeting @gedbrand10
Mark Peters (@madeinbrum87) says: 'no herrera? Confident line up glad to see di Maria back on bench and falcao start going for 3-1 United Rooney and falcao(2)'
But to today's form - United are looking for their seventh straight win as Louis van Gaal's finally finds the right formula after a shaky start, while Villa are after their third win in four games after their unbeaten run of five came to an end at West Brom last weekend.
Fancy a flutter? Sky Bet will give you 5/4 on Rooney to be an anytime goalscorer, or 9/2 to score first. Villa's Christian Benteke is 15/2 to be the first goalscorer.
Wayne Rooney loves playing Villa just as much as United do. He has 12 goals against them, more than any other side, and he starts today at what will be, for once, a packed out Villa Park.
Make no mistake, Villa Park is United's happy hunting ground. They've lost only once here in the Premier League, and that came 18 fixtures ago in 1995. 'You can't win anything with kids' was soon dispelled and Villa have been United's punch bag since. A whopping 103 points have been taken off the Midlands side by United in the Premier League, more than any other side.
And here are your teams... Aston Villa: Guzan, Okore, Vlaar, Clark, Lowton, Cissokho, Sanchez, Delph, Agbonlahor, Weimann, Benteke. Subs: Given, Bacuna, Herd, N'Zogbia, Robinson, Grealish, Calder. Manchester United: De Gea, Jones, Carrick, Evans, Valencia, Fletcher, Mata, Rooney, Young, Van Persie, Falcao. Subs: Lindegaard, Blackett, McNair, Rafael, Di Maria, Januzaj, Wilson
Good afternoon and welcome to Sky Sports' live coverage of Manchester United's trip to Aston Villa in the Premier League. Will United's run of six straight wins come to an end at their favourite Premier League stadium? Let me know your predictions by tweeting me at @gedbrand10, and I'll publish the best. Kick-off comes at 3pm.