Nicky Maynard's hat-trick earned Graham Coughlan his first win as Mansfield boss with a 3-2 success at Cambridge.
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Harvey Knibbs headed the home side into a third-minute lead that they held until nine minutes before the interval when Mal Benning's superb cross was diverted by Danny Rose into the path of Maynard, who turned the ball home from close range.
Cambridge responded and were back ahead a minute before the break when Jack Roles saw his free-kick rattle Conrad Logan's post but fall to Greg Taylor, who netted the rebound.
The U's were reduced to 10 men 14 minutes into the second half when Reggie Lambe was shown his second yellow card in three minutes and was dismissed for the second time in his last two starts.
Maynard's second of the afternoon drew Mansfield level on 71 minutes, as he fired in from close range following CJ Hamilton's centre, and he then headed the winner nine minutes from time when Cambridge were unable to clear a corner.