Hull City came from behind to beat Southampton 2-1 at the KCOM Stadium on Sunday afternoon after scoring twice in the space of just 125 seconds in the second half.
The Tigers, who were booed off at half-time, trailed at the break to Charlie Austin's sixth-minute penalty.
However, Hull turned the game on its head after the interval to claim all three points thanks to quick-fire strikes from substitute Robert Snodgrass and captain Michael Dawson.
Despite ending a run of six straight Premier League defeats, Mike Phelan's side remain in the relegation zone, while the Saints are in a mid-table position.
Hull were able to welcome back Dieumerci Mbokani and Snodgrass after hamstring and ankle injuries respectively, with both players fit enough to take their places on the substitutes' bench.
The visitors, meanwhile, recalled key trio Jose Fonte, Austin and Steven Davis, who all sat out Thursday's 2-1 home win against Inter Milan in the Europa League.
And it was Southampton who made the perfect start to the game after earning a penalty just six minutes in following a rash tackle by Hull centre-back Curtis Davies on Maya Yoshida, with referee Graham Scott having no hesitation in awarding a penalty.
Southampton's in-form striker Austin kept his cool from the spot by sending David Marshall the wrong way, with the ball nestling in the bottom left-hand corner of the net for the 27-year-old's eight goal in all competitions this season.
The home team's afternoon then went from bad to worse as only four minutes later they lost big-money forward Abel Hernandez to injury, before fellow frontman Will Keane fell victim to a nasty-looking knee problem midway through the first half.
But after Southampton - who could have seen Dusan Tadic sent off for a high tackle on Rayan Mason in the first half -central defender Virgil Van Dijk had struck the bar with a header six minutes after the break, the visitors' midweek exertions in Europe appeared to catch up with them, with Hull taking full advantage.
Firstly Harry Maguire missed a great chance to pull his team level, with the defender failing to hit the target from close range after being picked out by Snodgrass' inch-perfect free kick.
However, that was soon forgotten as just a minute later the Tigers were level after Sam Clucas made his way to the left-hand byline, before pulling the ball back perfectly for Snodgrass - on for the injured Keane - to rifle home from 10 yards out.
Incredibly, barely had anyone in the stadium been able to catch thweir breath before Hull found themselves in front in the game, and again that man Snodgrass was involved.
The Scotland international, who has a wand of a left foot, swung a free kick straight on to the head of Dawson, with the central defender rising highest to power a header high into the net past a helpless Fraser Forster.
Southampton tried manfully in the closing stages to rescue a point, with Austin being denied by Marshall and then a last-gasp Dawson block, before Clucas found himself in the right place to clear one final effort off the line in stoppage time.
Hull City: Marshall (8), Maguire (7), Davies (6), Dawson (8), Elmohamady (7), Henriksen (6), Livermore (6), Mason (7), Clucas (8), Hernandez (6), Keane (6)
Used subs: Huddlestone (6), Snodgrass (9), Mbokani (6)
Southampton: Forster (6), Yoshida (7), Fonte (6), van Dijk (6), Bertrand (7), Romeu (6), Clasie (6), Davis (6), Tadic (6), Redmond (6), Austin (7)
Used subs: Rodriguez (6), Ward-Prowse (6), Boufal (6)
Man of the Match: Robert Snodgrass