Henrikh Mkhitaryan is expected to start for Manchester United when they take on Feyenoord (8.05pm) in the Europa League on Thursday.
Jose Mourinho has confirmed the Armenian, who has made just one senior appearance since his half-time substitution against Man City in September, will feature at Old Trafford after being left out of United's 1-1 draw at home to Arsenal last Saturday.
With United sitting third in Group A, they could face elimination if they lose to their Dutch opponents and Fenerbahce beat Zorya Luhansk.
Mourinho's side have recorded two home wins and two away losses in Europe this season, and lost this reverse fixture 1-0 back in September after Tonny Vilhena's late winner for Feyenoord.
"We need four points to qualify - there is no space for a defeat," the United manager said. "Tomorrow becomes a game where we have only two options - win or draw. If we have a defeat we are out.
"We are going to approach the game knowing that. It is a knockout game for us. If we lose we are out so we cannot lose."
Luke Shaw is set to feature for the first time since being questioned by Mourinho over his apparent unwillingness to play through the pain barrier at Swansea two weeks ago.
Eric Bailly (knee) and Chris Smalling (toe) are both still ruled out, while Marouane Fellaini remains a minor doubt with a calf injury.
As mentioned, Mourinho has revealed summer signing Mkhitaryan will play some part against the Eredivisie side.
"He is getting closer and I told him on Saturday that he is going to be involved in the game against Feyenoord," Mourinho added. "He is trying.
"Obviously, he is not happy, but he is transforming his frustration in a good way, which is close the mouth and work hard and try to adapt."
These two sides have met just once before at Old Trafford in October 1997, with Man Utd winning 2-1 thanks to goals from Dennis Irwin and Paul Scholes.
Feyenoord have won just once in their last six visits to England in European competition (D2 L3), although that win did come in their most recent trip in September 2002, beating Newcastle 1-0.
The Red Devils have scored in 13 of their last 14 home games in European competition (inc. qualifiers), only failing to score against Dutch side PSV.
Feyenoord have kept clean sheets in three of their last four games against English sides in Europe, including each of the last two.
United have attempted more passes in the first four matchdays than any other Europa League side (2582 passes).
Manchester United have dominated possession in each one of their Europa League games this season - recording 65.2 per cent overall - a competition high average.
After scoring vs Fenerbache in the previous matchday, Rooney now has 38 goals in European competition for Man Utd - equalling the record set by Ruud van Nistelrooy.