Zlatan Ibrahimovic, Paul Pogba David de Gea and Antonio Valencia are set to return to Manchester United's starting line-up when they take on Hull City in the Premier League on Wednesday.
The quartet did not play in Sunday's FA Cup win against Wigan and are due to start as Jose Mourinho's men return to Premier League action.
"We always play a full strength team, depending on the way you look at it," Mourinho said. "But normally we always try to have always a strong team, but of course we had some players that didn't play the last match.
"Some players with a lot of matches already, players like (Antonio) Valencia, Pogba, Ibrahimovic, didn't play (against Wigan). They will play tomorrow."
Andrea Ranocchia could make his debut for Hull on Wednesday night.
With Curtis Davies ruled out for around eight weeks with a hamstring injury and fellow centre-halves Michael Dawson and Harry Maguire struggling with knocks, Ranocchia could slot in at the back after completing his loan switch to the Tigers from Inter Milan on Deadline Day.
Eric Bailly, back from the Africa Cup of Nations, is available for United, while Mourinho confirmed Ashley Young will be staying at the club and involved.
Ahmed Elmohamady (Egypt) and Dieumerci Mbokani are both on Africa Cup of Nations duty and unavailable for the trip to Old Trafford.
Hull have picked up just one point in nine Premier League meetings with Manchester United (W0 D1 L8).
This will be the third competitive meeting between these two teams inside 23 days, with them playing each other twice in the EFL Cup before this game.
Manchester United are on the current longest unbeaten run in the Premier League (13 games - W7 D6 L0).
This is the Red Devils' longest unbeaten run in the Premier League since March 2013; an 18-game run under Sir Alex Ferguson.
Manchester United have already attempted more shots on target in their 11 league games at Old Trafford this season (77) than they did in the whole of last season at home (75).
No player has as many goals (7), has as many assists (3), has created as many chances (45) and has had as many shots (39) for Hull City in the Premier League this season than Robert Snodgrass.
Wayne Rooney has now scored in 148 different Premier League matches. The only players to score in more are Alan Shearer (190), Frank Lampard (149) and Andrew Cole (149).
Hull are playing well under Marco Silva but I United cannot go against at Old Trafford. I know Hull beat them in the EFL Cup semi-final second leg but United played like a team that were two goals up.
They beat Hull convincingly in the first leg and I see them repeating the feat on Wednesday to maintain Jose Mourinho's "unbeaten" run!
PAUL PREDICTS: 2-0 (9/2 with Sky Bet)
Hull can be backed at 14/1 with Sky Bet, who hold Manchester United as 2/11 favourites while pricing up the draw at 6/1. The hosts are 3/1 to win by exactly one goal and it's the same price for a two-goal margin in United's favour.
Zlatan Ibrahimovic is the 5/2 favourite in the first goalscorer betting, with Abel Hernandez considered the visitors' main threat at 14/1 to net first.