Dominic Calvert-Lewin is expected to start against Wales on his England debut on Thursday.
The Everton striker has been called up to the senior squad for the first time after scoring nine goals already this season.
Gareth Southgate's squad has been hit by a number of absentees from what was originally a 30-man squad ahead of their first game at Wembley since the coronavirus pandemic broke out in March.
Tammy Abraham, Ben Chilwell and Jadon Sancho are all ruled out after attending Abraham's surprise birthday party on Sunday, the day before the trio were due to link up with their team-mates at St George's Park.
Raheem Sterling has also withdrawn through injury.
Calvert-Lewin, 23, said earlier this week he could not wait to work with fellow England striker Harry Kane after receiving his first call-up.
Kane has registered eight goals and seven assists in eight games for Spurs this season.
"I'm always learning and he has been scoring goals for a long period of time," Calvert-Lewin said of Kane. "He broke into the Premier League and hit the ground running around the same age as me.
"He's got a lot of things to his game I can learn from and I can add that to my game. He is where he is for a reason. He's worked extremely hard, he's got great ability and he scores goals.
"For me as a player coming into the team, it's nice to get up close and personal and see how he operates on a daily basis."
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