Manchester United will host rivals Leeds United at Old Trafford on the opening weekend of the 2021/22 Premier League season.
United face a possibly season-defining run of games in October and November, which starts with a trip to Leicester on October 16, the first showdown with Liverpool at Old Trafford on October 23, and a visit to Tottenham on October 30.
November 6 marks the first Manchester derby of the season as champions Manchester City travel to Old Trafford, before United head to Champions League winners Chelsea on November 27 before rounding off the month by hosting Arsenal on November 30.
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United face Newcastle and Burnley during the festive period and then host Wolves on New Year's Day before embarking on their winter break.
March and April will take on huge significance in United's season, with Manchester City, Tottenham, Liverpool, Leicester and Everton fixtures back to back, before Chelsea head to Manchester in the penultimate game of the season and United end their campaign away at Crystal Palace.
All fixtures subject to change.
14: Leeds United (h) - 12.30pm
22: Southampton (a) - 2pm, live on Sky Sports
29: Wolves (a) - 4.30pm, live on Sky Sports
11: Newcastle (h) - 3pm
18: West Ham (a) - 3pm
25: Aston Villa (h) - 3pm
2: Everton (h) - 3pm
16: Leicester (a) - 3pm
23: Liverpool (h) - 3pm
30: Tottenham (a) - 3pm
6: Man City (h) - 3pm
20: Watford (a) - 3pm
27: Chelsea (a) - 3pm
30: Arsenal (h) - 8pm
4: Crystal Palace (h) - 3pm
11: Norwich (a) - 3pm
14: Brentford (a) - 7.45pm
18: Brighton (h) - 3pm
26: Newcastle (a) - 3pm
28: Burnley (h) - 3pm
1: Wolves (h) - 3pm
15: Aston Villa (a) - 3pm
22: West Ham (h) - 3pm
8: Burnley (a) - 7.45pm
12: Southampton (h) - 3pm
19: Leeds (a) - 3pm
26: Watford (h) - 3pm
5: Man City (a) - 3pm
12: Tottenham (h) - 3pm
19: Liverpool (a) - 3pm
2: Leicester (h) - 3pm
9: Everton (a) - 3pm
16: Norwich (h) - 3pm
23: Arsenal (a) - 3pm
30: Brentford (h) - 3pm
7: Brighton (a) - 3pm
15: Chelsea (h) - 3pm
22: Crystal Palace (a) - 4pm
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The 2021/22 Premier League will start on Saturday August 14 - 34 days after the Euro 2020 final at Wembley.
The season will end on May 22 2022, with all 10 games kicking off at the same time.
The 2021/22 EFL season will kick-off on Saturday August 7.
Next season's League One campaign will finish on the weekend of April 30 2022, with League Two and the Championship on one of May 7 and May 8 respectively.
The League One play-off final will then be held on Saturday May 21, the League Two play-off final on Saturday May 28, and the Championship play-off final on Sunday May 29.