Robin van Persie has withdrawn from the Dutch squad to face Macedonia on Wednesday with a groin injury.
Arsenal ace withdraws from squad with groin injury
Robin van Persie will play no part in Holland's World Cup qualifying match against Macedonia on Wednesday due to a groin injury.
The Arsenal striker has left the Netherlands training camp in news that will alarm his club manager Arsene Wenger.
Van Persie had looked to have been returning to form of late after missing much of the campaign with a succession of injuries.
He was on target for the Dutch in Saturday's comfortable 3-0 victory over Scotland, but has now been sidelined with a fresh problem.
Van Persie's place is likely to be taken by Wesley Sneijder, who was overlooked in his favoured attacking midfield role at the weekend as the Arsenal man was given the nod.
The Netherlands lead Group 9 with 12 points from four games.