Northern Premier League Division One side Marine will host Premier League leaders Tottenham in the third round of the FA Cup.
Marine became only the second side from the eighth tier to reach the third round after beating Havant & Waterlooville after extra-time on Sunday.
Holders Arsenal begin their campaign at home to Newcastle while Aston Villa will host Liverpool in another all-Premier League tie, with all third round fixtures scheduled to be played on the weekend of January 8-11 2021.
Twelve-time winners Manchester United will host Championship side Watford at Old Trafford, while last season's runners-up Chelsea host League Two Morecambe.
National League North side Chorley will play Derby at home and Stockport, of the National League, have also been handed home advantage in their tie against West Ham.
National League side Boreham Wood, who won 3-0 at Canvey Island on Monday evening, will face Millwall at home.
'Mourinho meeting just reward for Marine'
"It's an unbelievable feeling, to bring the Premier League leaders to our tiny little ground, it's fantastic," Marine manager Neil Young told Sky Sports News.
"The England captain, the Wales captain, Jose Mourinho coming to Marine is just rewards for our lads for getting this far. To pull Spurs out of the hat is a fantastic feeling for the club.
"We're one of the lowest teams still in it, everyone is looking forward to it. Cheers went out in the houses around the ground, it was crazy.
"We're a fairly young team, they've enjoyed it, to draw Tottenham out of the hat is just unbelievable."
FA Cup third-round draw in full:
Huddersfield Town vs Plymouth Argyle
Southampton vs Shrewsbury Town
Chorley vs Derby County
Marine vs Tottenham
Wolves vs Crystal Palace
Stockport County vs West Ham
Oldham vs Bournemouth
Manchester United vs Watford
Stevenage vs Swansea
Everton vs Rotherham United
Nottingham Forest vs Cardiff
Arsenal vs Newcastle United
Barnsley vs Tranmere Rovers
Bristol Rovers vs Sheffield United
Boreham Wood vs Millwall
Blackburn Rovers vs Doncaster Rovers
Stoke City vs Leicester
Wycombe vs Preston North End
Crawley Town vs Leeds United
Burnley vs MK Dons
Bristol City vs Portsmouth
QPR vs Fulham
Aston Villa vs Liverpool
Brentford vs Middlesbrough
Manchester City vs Birmingham City
Luton Town vs Reading
Chelsea vs Morecambe
Exeter City vs Sheffield Wednesday
Norwich City vs Coventry City
Blackpool vs West Bromwich Albion
Newport County vs Brighton & Hove Albion
Cheltenham Town vs Mansfield Town