Sammy Ameobi and Ayoze Perez scored their first Premier League goals as Newcastle came from behind to win 2-1 at Tottenham.
Alan Pardew's half-time substitutions inspired Newcastle to a much-needed victory.
The Magpies are now up to 14th place in the table after recording only their second top-flight win of the season, while Spurs drop to 11th.
Emmanuel Adebayor put the hosts in front in the 18th minute at White Hart Lane with his first goal since August.
After Nacer Chadli and Christian Eriksen both had close-range shots blocked, Ryan Mason's cross from the left was headed home by Adebayor at the far post.
Best of the Match
- Man of the Match: Sammy Ameobi had only been on the pitch for around eight seconds when he equalised and he was impressive for the rest of the second half too.
- Goal of the Match: Ameobi's superb equaliser - a shot rifled across Lloris from left to right after Colback's pass through - was his first in the Premier League.
- Moment of the Match: Midweek hero Harry Kane sent a ball across the face of goal late on but no Spurs player was able to turn it home.
- Talking Point: Could Newcastle jump above Tottenham in the table next weekend? The Magpies host an out-of-sorts Liverpool while Spurs go to Aston Villa.
Pardew threw on Ameobi and Remy Cabella at the start of the second half.
And within eight seconds of kick-off, Jack Colback sent the ball through for Ameobi to latch onto in the left channel and he finished brilliantly across Hugo Lloris.
Then on 58 minutes, the Lane was stunned into silence as Perez - on his full Toon debut - rose to head in Cabella's cross to put the away side ahead.
Despite late pressure from Spurs, the visitors held on to take all three points - a timely shot in the arm for under-fire Pardew, who built on their maiden win against Leicester with a first away victory for seven months.
It had looked unlikely after Adebayor deservedly put Mauricio Pochettino's side ahead in the Bill Nicholson anniversary match, marking 10 years since Tottenham's great former player and manager passed away.
But it was Newcastle, a club Nicholson represented as a guest during the Second World War, who ultimately secured victory.
Spurs were dominant, if uninspiring, in the first half and they appealed for a spot-kick against Daryl Janmaat inside the opening two minutes.
Jan Vertonghen, Eriksen and Ryan Mason all failed with long-range efforts, before Newcastle left-back Paul Dummett missed an audacious attempt of his own from 40 yards.
Colback wasted a fine opportunity when the normally-reliable Lloris unconvincingly punched away a Moussa Sissoko cross, before a rare moment of class led to an 18th-minute breakthrough.
Last-ditch blocks kept Chadli and Eriksen at bay, but Mason showed impressive ingenuity to clip in a cross for Adebayor to direct home.
It was an impressive header which proved the only difference at half-time as Spurs failed to create any further shots on target.
Danny Rose was unable to keep an effort down after an impressive Erik Lamela prod put him through, before the left-back saw a hopeful appeals for a spot-kick rightfully waved away.
Chadli wastefully blazed over a volley at the end of an uninspiring first half in which Newcastle looked poor.
Cabella and Ameobi were brought on in a bid to change things, but Pardew could not in his wildest dreams imagined their impact.
Five touches and around eight seconds was all it took for Newcastle to pull themselves level, with Eric Dier caught napping from a fine Colback pass which substitute Ameobi rifled home.
Pochettino and many of the Spurs substitutes were not even back at their seats when the goal was breached - a shock to the system Spurs could have recovered almost immediately had Fabricio Coloccini not impressively denied Eriksen turning home a squared ball from Rose.
That block saw Newcastle remarkably turn the match on its head.
Despite having looked to receive a pass from Sissoko in an offside position, second-half introduction Cabella sent in a cross which full debutant Perez headed home.
The visitors' relief was clear by the wild celebrations which would have been repeated had Cabella ended a solo run by squeezing his effort inside the near post rather into the side-netting.
It was a let-off the home faithful thought they had capitalised on in the 66th minute when Eriksen caught out Tim Krul directly from a corner, but the Newcastle goalkeeper's blushes were saved by linesman indicating the cross had gone out of play before curling back in.
Harry Kane, fresh from coming on, could not beat Krul with his first attempt of the afternoon as Spurs upped the ante, with Aaron Lennon failing to hit the target.
A low, driven cross from Kane somehow evaded his team-mates and Roberto Soldado had an effort blocked as a leveller proves beyond them.