Virat Kohli completed his 36th ODI hundred and shared a stand of 246 with fellow centurion Rohit Sharma as India eased to their target of 323 to beat Windies by eight wickets in Guwahati.
Windies batsman Shimron Hetmyer's 74-ball ton had set the hosts a seemingly challenging chase in the first game of the five-match series, only for Kohli (140 off 107 balls) and Rohit (152no off 117) to break the back of India's reply after Shikhar Dhawan (4) fell in the second over to debutant Oshane Thomas.
Kohli was eventually stumped off Devendra Bishoo, leaving Rohit, whose hundred was his 20th in ODI cricket, and Ambati Rayudu (22no) to steer the hosts home with 47 deliveries in reserve.
Hetmyer (106 off 78) earlier sealed his third ODI century in his 13th match with a six off Mohammed Shami, while Kieran Powell (51 off 39) scored a half-century up top and Kemar Roach (26no) and Bishoo (22no) added an unbroken 44 for the ninth wicket as Windies posted 322-8.
Powell bossed a second-wicket stand of 56 with Shai Hope (32) after the exit of Chandrapaul Hemraj (9), but Windies slipped to 114-4 once they were removed, with their dismissals sandwiching Marlon Samuels' duck.
Hetmyer, though, launched six sixes and as many fours as he added 74 with Rovman Powell (22) and 60 with skipper Jason Holder (38) before he was caught in the deep in the 39th over slog-sweeping Ravindra Jadeja, a bowler he had blazed three of his maximums off.
Jadeja and Yuzvendra Chahal (3-41) stemmed the run rate with the latter accounting for Holder and Ashley Nurse (2), only for Bishoo and Roach to frustrate India, who beat Windies 2-0 in the preceding Test series following thumping wins in Rajkot and Hyderabad.
Kohli's men made a winning start to the ODI series, too, with Kohli striking 21 fours and two sixes and Rohit nailing eight sixes and 15 fours - Rohit's final maximum, off Hemraj, cementing a crushing victory and taking him to his sixth score of 150 or better in ODIs.
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