Ryan Tannehill starred as the Tennessee Titans continued their 100 per cent record this season with a victory that ended the Buffalo Bills' perfect run.
Michael Badgley missed a 50-yard game-winning field goal try as the Los Angeles Chargers were beaten 30-27 by the New Orleans Saints in overtime.
The Atlanta Falcons fired head coach Dan Quinn and general manager Thomas Dimitroff after the team slipped to 0-5 to start the season.
The Saints will be without Michael Thomas when they host the Chargers on Monday night after being benched for 'disciplinary reasons'.
Justin Herbert was one of the NFL Draft's polarising quarterbacks, but he has already made a lasting impression. Have the Los Angeles Chargers found their man?
The contrasting fortunes of quarterbacks Alex Smith and Dak Prescott lead the headlines from Week Five in the NFL.
Dallas Cowboys quarterback Dak Prescott has surgery on his right ankle after sustaining a season-ending injury against the New York Giants.
Russell Wilson threw a touchdown to D.K. Metcalf with 15 seconds left as the Seahawks came back from a 13-point deficit to defeat the Vikings 27-26.
Baker Mayfield outduelled Philip Rivers on a mixed night for both quarterbacks as the Cleveland Browns beat the Indianapolis Colts 32-23 to move to 4-1.
The Las Vegas Raiders put up 490 yards of total offense and 40 points as they outpaced Patrick Mahomes and the Kansas City Chiefs.
Recap the Raiders' stunning win over the Chiefs, Cleveland's win over Indianapolis and all the best from Week Five.
Odell Beckham Jr. reminded the NFL of his genius against the Dallas Cowboys in Week Four - is this the start of the wide receiver's resurgence?
Cairo Santos kicked the winning field goal as Nick Foles and the Chicago Bears rallied to beat the Tampa Bay Buccaneers in the opening game of Week Five.
Thursday night football will see Tom Brady and Nick Foles meet for the first time since their memorable Super Bowl LII clash.
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