Ezekiel Elliott had two fumbles and Andy Dalton two interceptions as the Dallas Cowboys were trounced 38-10 by the Arizona Cardinals.
Kansas City Chiefs rookie running back Clyde Edwards-Helaire rushed for 161 yards as they toppled the Buffalo Bills 26-17 on Monday night.
Buffalo Bills QB Josh Allen has been described as being the most like reigning Super Bowl MVP, Patrick Mahomes, ahead of their Monday matchup.
Derrick Henry's 200-yard rushing performance and the Denver Broncos' impressive defensive display against the New England Patriots lead the Week Six headlines.
Jimmy Garoppolo threw three touchdowns as the San Francisco 49ers beat the Los Angeles Rams 24-16 in a match-up of the last two NFC champs.
Aaron Rodgers was intercepted twice as Tom Brady's Tampa Bay Buccaneers routed his Green Bay Packers 38-10 in their third career meeting.
The Pittsburgh Steelers moved to 5-0 for the first time since 1978 as they harassed Baker Mayfield and the Cleveland Browns to run out 38-7 winners.
Tom Brady and Aaron Rodgers meet for the third and possibly final time this Sunday - are we looking at the greatest of all time versus the best of all time?
The Pittsburgh Steelers suffered a down year last season, but they are back atop the AFC North and are a major contender in 2020.
Seattle Seahawks receiver D.K. Metcalf is currently 'the best in the NFL', according to Good Morning Football's Kay Adams.
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