Solheim Cup captain Catriona Matthew will focus her attentions on the Ladies European Tour after announcing she will play her last tournament on the LPGA Tour in July.
Matthew will make her bow from regular US competition at the Dow Great Lakes Bay Invitational in Michigan, which takes place from July 17-20, where she will partner Suzann Pettersen.
The 49-year-old Scot will also play in the AIG Women's British Open and ASI Ladies Scottish Open, which are co-sanctioned by the LPGA and Ladies European Tour.
"This is my 25th year on the LPGA and I decided it was time," Matthew said ahead of the La Reserva de Sotogrande Invitational event.
"I've had a good career and everything comes to an end.
"It just hit me and I thought 'This is it'. I missed the cut in LA about a month ago and realised I'd had enough of the grind, being week in, week out and then going back home and having to practice, with the kids. It just got old.
"I'm not quitting. I'll play in Europe and I'm keen to play in the US Senior Open next year. I'm moving my focus to try and win that."
Dame Laura Davies won the inaugural US Senior Women's Open by 10 shots last year and will defend her title this week.