In just his 16th professional bout, London's knockout sensation has the chance to add the IBF world heavyweight title to his Olympic super-heavyweight gold medal. Standing in his way is a towering and unbeaten American southpaw in Charles Martin.
Although some of his fans fear Joshua's inexperience and Martin's power, most expect a stacked card of boxing to climax in glory for the fighting pride of Watford.
Relations between champion and challenger have been pleasant throughout with neither fighter fond of 'trash talk' - but when the first bell goes that mutual respect will count for nothing. With Joshua's record a flawless run of knockouts and Martin stopping all but two of his 23 victims, fireworks seem inevitable.
Image:Charles Martin v Anthony Joshua
Image:Physical measurements - Martin vs Joshua
What the fighters say
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IBF heavyweight champion Charles Martin is confident
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Why Anthony Joshua feels he has the edge over Charles Martin
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Charles Martin promises a knockout
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Anthony Joshua is expecting a heavy hitting fight
What the camps say
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Charles Martin's trainer Henry Tillman warns Anthony Joshua
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Tony Sims admitted that Anthony Joshua can't fight on emotion
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Charles Martin's camp manager Paul Cain is positive
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Eddie Hearn believes Anthony Joshua can be a superstar
What the experts say
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Glenn McCrory feels the step up may be too soon
It's a good fight and I can't say 100 per cent what's going to happen but I'd slightly favour Martin. I think there'll be a stoppage either way.
I think Joshua wins on points. Don't get me wrong, he could wipe Martin out - but I hope his trainer is telling him to 'box and move' and beat this guy on points.
Martin knows he's never been that deep in a fight and so they'll try to get him into the later rounds. Anybody would be mad to try and mix it with AJ early on, so I see Joshua stopping him in eight rounds.
If Martin is too hesistant, Joshua will take him out, and that's what I see happening. Once Martin gets hurt, he'll make mistakes, and that's where the crisp punching of Joshua will make the difference in the middle rounds.
The weigh-in
Martin: 17st 7lbs
Image:Charles Martin weighed in heavier than Anthony Joshua
Joshua: 17st 6lbs
Image:Anthony Joshua salutes the crowd after weighing in
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The head-to-head
The time draws near...
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Also on the bill, Lee Selby v Eric Hunter, Jamie McDonnell v Fernando Vargas, George Groves v David Brophy, Matthew Macklin v Brian Rose, Conor Benn v Ivailo Boyanov and Ohara Davies v Andy Keates.