Saracens slumped to their first defeat in six months as Harlequins stunned the double winners 17-10 at the Stoop.
Dai Young eased fears over Danny Cipriani after the fly-half left the field with a head injury in Wasps' victory over Saints.
The Scarlets ended a run of five defeats to claim their first win of the season in a tight 17-8 defeat of Connacht.
Conor Murray's brace of tries helped Munster emerge as 28-14 bonus-point winners over Edinburgh at Thomond Park.
Wasps maintained their unbeaten start to the Aviva Premiership season with a 20-15 victory against a sloppy Northampton.
John Kingston praised the reinforcements that helped Harlequins overcome a mass of injuries to claim victory over Saracens.
Cardiff Blues survived a scare from Zebre on Saturday to notch their fourth victory in as many games.
Barbarians v South Africa
5th November 2016
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