Chris Gayle's joint-fastest T20 fifty in history failed to fire Melbourne Renegades into the Big Bash semi-finals as the hosts went down to table toppers Adelaide Strikers by 27 runs at Etihad Stadium.
Gayle reached his half-century from 12 deliveries, matching the achievement of Yuvraj Singh for India against England at the 2007 ICC World T20 in South Africa, before falling to Australia new boy Travis Head (3-16) for a 17-ball 56.
Renegades, who needed to chase down Strikers' 170-5 in 16 overs to take Sydney Thunder's place in the top four on run rate, wilted to 143 all out after Gayles' exit, meaning Thunder will head to Strikers for the first semi-final on Thursday before Melbourne Stars host reigning champions Perth Scorchers a day later.
Strikers raced to 82-0 from 10 overs after being put into bat, with Jono Dean, opening in the absence of the injured Mahela Jaywawardene, creaming four sixes in his 35-ball 48.
Dean's dismissal - the right-hander caught and bowled by Dwayne Bravo - triggered a collapse, Strikers losing four wickets for 22 runs, including Head (0) and Dean's fellow opener Tim Ludeman (49 from 41), with spinner Xavier Doherty snaring two wickets.
However, skipper Brad Hodge (37no from 21) and Jake Lehmann (24 from 16) combined to add 55 in 5.1 overs, the latter, the son of Australia coach Darren, impressing again after nailing a match-winning six in the last-ball victory over Hobart Hurricanes last time out.
Gayle got Renegades' reply off to a pulsating start, blazing Greg West for four successive sixes in the opening over and then cracking three more maximums en route to his rapid-fire fifty, the quickest in domestic T20, beating Marcus Trescothick's 13-ball effort for Somerset against Hampshire in 2010.
The left-hander received little support, though, with Tom Cooper and Bravo falling for first-ball ducks and captain Cameron White making just six, and Gayle was banished to the shed himself in the sixth over after top-edging Head into Ludeman's gloves.
Gayle's dismissal came amid Renegades shipping seven wickets for 33 runs and falling to 97-8 - Peter Nevill (21) the only other man in the top seven to reach double figures - and a spirited ninth-wicket stand of 44 between Nathan Rimmington (26) and Cameron Gannon (23) could not save the hosts, who were dismissed in 15.3 overs.
Watch both Big Bash semi-finals - and Sunday's final - live on Sky Sports.