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Can anyone stop Serena Williams winning the US Open?

Injury has forced Serena Williams out of next week's hard court event in California

We look at five potential challengers for Serena Williams as she bids to win a fourth straight US Open and a calendar Grand Slam.

The American is a strong favourite to triumph in New York and secure the 22nd major of her career.

But who could stop her from lifting the trophy on September 12? We examine where her toughest tests could come from…

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Ana Ivanovic

Ana Ivanovic US Open 2015 adidas kit
Image: Ivanovic doesn't hold a favourable record against Williams

The head-to-head might read 9-1 in Serena's favour, but Ivanovic pushed the American close the last time they met in Cincinnati.

After breaking three times to take the first set 6-3, the Serb also held a 2-0 lead in the decider, before going down 3-6 6-4 6-2.

"In the third set I started well, but I physically just couldn't keep up that level," Ivanovic said afterwards.

It was a familiar story in their recent match-ups, with four of the previous six meetings going to three sets and only one resulting in a victory for Ivanovic.

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If the former world No 1 can improve her staying power then she could cause Serena problems in New York if they meet in the semi-finals.

Victoria Azarenka

Victoria Azarenka
Image: Will Azarenka be fully fit in New York?

Provided she is 100 percent fit, then Azarenka could pose one of the biggest threats for Williams in the Big Apple.

The former world No 1 withdrew from Cincinnati in the second set of her third-round match against Anastasia Pavlyuchenkova as she did not want to aggravate a leg injury.

"I started to feel like it was getting a little bit worse and such a short period of time before the US Open it's a little bit dangerous. I had to unfortunately make that decision," she said afterwards.

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Serena Williams will claim her first calendar-year Grand Slam if she wins the US Open

While Azarenka will probably be pleased to be on the other side of the draw to Williams, given she has lost to her twice in the final in New York before, she pushed the American to the limit in their recent meetings.

Five of their last six matches have gone to three sets and Azarenka will probably feel she should have won more than just one of them.

In Madrid earlier this year she squandered three matches points, at the French Open she lost 10 of the last 12 games to lose in three sets and at Wimbledon she was beaten 3-6 6-2 6-3 in a high-quality match.

They contested a captivating US Open final in 2013 and could meet again this year.

Sloane Stephens

Sloane Stephens kisses the trophy after defeating Anastasia Pavlyuchenkova in Washington
Image: Sloane Stephens won a Washington title recently

After ending her lengthy wait for a first WTA title, Stephens should enter the US Open in high spirits.

The 22-year-old had been 0-6 in semi-finals and had never reached a final in 83 previous tournaments before winning the Citi Open in Washington at the start of August.

She has already faced Serena three times this year and on two occasions – in Indian Wells and Paris – took the world No 1 to three sets.

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Serena Williams says she is not feeling the pressure as she bids to complete a grand slam set by winning the US Open

Her performance at the French Open in particular should give her confidence as she led 6-1 5-4 before a stirring fightback wrestled victory away from her.

Stephens and Williams are scheduled to meet in the third round in New York and the older American is expecting a tough challenge.

"I seem to play Sloane every tournament," Williams said. "It's not anything simple or easy to deal with. Sloane is playing excellently."

Sam Stosur

Sam Stosur is a two-time winner on clay this year
Image: Sam Stosur beat Williams at the US Open in 2011

The Big Apple holds fond memories for the Australian as it was here in 2011 that she won her first and only major, beating Serena 6-2 6-3 in the final.

With Serena having won all three editions of the US Open since, Stosur is still the last player to beat the American in New York.

In 2015 she has won clay-court titles in Strasbourg and Bad Gastein and also reached the semi-finals of the hard-court Citi Open in Washington.

Asked about the prospect of facing Williams at the US Open, Stosur told the Courier Mail: "I've always actually quite enjoyed playing Serena. I've got a game that disrupts her.

"You have to have the game. My game matches up well against Serena. I've got the kind of weapons that can bother her. If I do A, B and C well, then I've got a chance."

Seeded 22nd, Stosur is on the other half of the draw to Williams so could only meet her in the final.

Belinda Bencic

Belinda Bencic holds the Rogers Cup following her win over Simona Halep in Toronto
Image: Belinda Bencic holds the Rogers Cup following her win in Toronto

One of the rising stars of the women's game, 18-year-old Bencic heads to New York just a few weeks after recording one of the most impressive tournament wins of the year in Toronto.

The Swiss beat six former major winners or finalists on her way to lifting the trophy, including Caroline Wozniacki, Ana Ivanovic, Williams and Simona Halep.

She followed it up with straight-set wins over Angelique Kerber and Flavia Pennetta in Cincinnati before withdrawing against Lucie Safarova as a precautionary measure with an injury.

"I don't think it's very serious," she said afterwards. "I just wasn't 100 percent today, and to beat Lucie or even compete against her, you need to be 100 percent. I'm really sorry I had to retire.

"It was the first time ever I've retired from a match, so it didn't feel very good."

Bencic is expected to be fit for the US Open, where she impressed last year as a 17-year-old, beating sixth seed Kerber and ninth seed Jelena Jankovic on her way to the quarter-finals.

She could face Williams in the quarter-finals in New York this year.

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