Arsenal will go to Old Trafford to face Manchester United as the bookies' favourites for the first time in the Premier League era.
The Gunners are 7/5 to win at Old Trafford with Sky Bet, while United are 2/1 to pick up all three points against the side currently 10 points above them in the Premier League.
Arsenal are two points off leaders Leicester, and although former United striker Danny Welbeck gave them a 2-1 win at United last season in the FA Cup sixth round, they have not won there in the Premier League since September 2006.
Emmanuel Adebayor grabbed an 86th-minute winner that day, and since then Arsene Wenger's side have lost six and drawn two of their eight league meetings.
Even their Old Trafford meetings during Arsenal's 49-game undefeated run from 2003 to 2004, which ended at Old Trafford in a 2-0 defeat, pipped them as slight underdogs.
That now-infamous first defeat in October 2004, which saw Ruud van Nistelrooy and Wayne Rooney score to end Arsenal's unbeaten run, had United as marginal favourites pre-match at 13/8, with Arsenal 7/4.
The longest Arsenal have been for a win at Old Trafford came in August 2011, going into the game 7/1 before falling to an 8-2 defeat.