Will Grigg, Gavin Massey and Dan Burn were on target for League One leaders Wigan Athletic as they ended Plymouth's eight-match unbeaten run with a 3-1 comeback win at Home Park.
Plymouth took a 27th-minute penalty lead through goal-scoring playmaker Graham Carey.
Carey had been fouled by Chey Dunkley cutting in from the left after fellow midfielder David Fox had found him with a superb cross-field ball.
Argyle's joy was relatively short-lived as Wigan levelled in their next attack, Nathan Byrne crossing from the right and Grigg sliding in to convert and restore parity on 29 minutes.
In first-half stoppage-time, Wigan countered at pace from their own half through Max Power in midfield and his ball through to Massey was turned in past a diving Remi Matthews and into the corner.
Power provided the cross - from a 69th-minute corner - which towering central defender Burn headed home to make it 3-1.
Carey nearly scored with his 47th-minute free-kick which Wigan's goalkeeper Christian Walton had to punch away as the visitors claimed maximum points to move five clear at the top.