Joshua puts his IBF, WBA and WBO gold on the line against his mandatory challenger, the dangerous Povetkin who arrives in London armed with a fearsome mentality and a brutal left hook.
Huge opportunities to unify the division may await for Joshua who has a return to Wembley booked for April but he will not be able to overlook his 39-year-old visitor, who has only lost one fight in 35 to a prime Wladimir Klitschko.
What the fighters say
Skills and technique apart, we both have a big heart and can dig deep. The one who's toughest will come out victorious.
AJ is one of the strongest in the division, I'm happy to have this opportunity and we will give the fans a good fight. The fight will show everything, Anthony is a very strong fighter but I am just as strong.
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AJ & Bellew study the tactics
What the promoters say
He has to be spiteful, and he needs to know that he can hurt Povetkin. We need to see a little bit more ruthlessness from Joshua while also being smart.
This is the biggest fight in heavyweight boxing, right now. Wilder and Fury are great fighters but there is a lot of hype. Povetkin is the real test for Joshua.
What the trainers say
This is a fighter from a different level, with respect to Parker and Takam. Povetkin comes from the top level.
Every boxer has some weaknesses. But, the key moment is how can you use it?
What their rivals say
[Joshua] had a tremendous amount of problems with Carlos Takam, who comes forward like Povetkin, throws combinations like Povetkin.
I think Povetkin is a bit too old and long in the tooth now, and he's had too many hard fights.
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Tune in at 6pm... this will get you going!
Watch Joshua vs Povetkin, at Wembley Stadium, on September 22, live on Sky Sports Box Office, from 6pm. Book via your Sky remote or book it online here.