Matthew Stafford threw five touchdown passes as the Detroit Lions claimed a 45-14 win over the Philadelphia Eagles.
Live updates from a triple header of NFL fixtures on Thanksgiving Day - watch live on Sky Sports 1 HD.
Our US fantasy expert Alex Ferguson is back with more advice as you worry about your team selection for week 12.
NFL's Week 12 match-ups are analysed by Sky Sports News HQ's Richard Graves who offers his predictions.
Sky Sports will serve up a Thanksgiving Day triple-header of live NFL games.
Cam Newton played an NFL game with microphones attached to his jersey - and you can hear what he said!
Two-time Super Bowl winner Osi Umenyiora on why Thanksgiving is an important day for NFL.
Watch this video as we count down the best Fantasy performers from Week 11, including Thomas Rawls.
The latest International Series NFL matches in the UK have been revealed with Wembley and Twickenham to host games in 2016.
Alex Ferguson rounds-up what NFL fans should be grateful for this Thanksgiving.
We remember five key matches from the NFL's history at Wembley, after the 2016 games were revealed.
St. Louis Rams receiver Stedman Bailey is in a critical condition in hospital after being shot.
Laura Woods is joined by NFL.com's fantasy expert Adam Rank for this week's edition of 'NFL on the Wire'.
Neil Reynolds and Jeff Reinebold discuss the latest news from the NFL in their weekly podcast.
Tom Brady was denied a touchdown for the New England Patriots due to an embarrassing blunder by match officials.
The Patriots ground out a bruising 20-13 victory over the Buffalo Bills to extend their unbeaten start to the season.
The NFL has opened an investigation into the St Louis Rams after quarterback Case Keenum suffered a concussion on Sunday.
Watch our top five moments from Week 11 featuring Brock Osweiler, Tony Romo and Cam Newton.
Denver Broncos quarterback Peyton Manning will be absent again this week as he seeks a second opinion on a foot problem.
Check out the top five touchdowns from NFL Week 11 - including Andre Roberts and DeAndre Hopkins.