Preston North End's Lukas Nmecha has pulled out of England U20's games against Switzerland and the Netherlands due to a knock.
The Manchester City loanee had already missed Saturday's 2-2 draw against Bolton Wanderers after making six appearances for the Lancashire club.
The striker was expected to make his debut for Paul Simpson's side, victorious in last year's U20 World Cup in South Korea, after representing England at U16, 17, 18, 19 and 21 level.
England play Switzerland at St George's Park on Thursday, before travelling to Katwijk to play the Netherlands on Monday.