Champion Golfer of the Year Shane Lowry and former Masters champion Danny Willett are among the players looking to extend their PGA Tour seasons at the Wyndham Championship.
The event at Sedgefield Country Club marks the final event of the regular PGA Tour campaign, with only the top 125 in the FedExCup standings after this week then progressing to the season-ending FedExCup play-offs.
At least two players have played themselves into the top-125 in each of the last five editions of the event, with Andrew Landry and Patton Kizzire both managing it after top-20 finishes in last year's contest.
Lowry arrives 131st in the standings after following a share of sixth at the WGC-FedEx St Jude Invitational with a disappointing week at the PGA Championship, leaving him requiring at least a top 30 finish in North Carolina to have a chance of breaking into the top 125.
Fellow Europeans Matt Wallace and Rafa Cabrera Bello are immediately below the Irishman in the rankings, while Danny Willett lies in 143rd position after missing the cut at the opening major of the year last week.
Former Masters champion Charl Schwartzel heads into the week 125th in standings for the second time in six years, with Scotland's Russell Knox one point ahead of him after ending a run of 10 consecutive missed cuts with a tied-25th finish at the Barracuda Championship.
England's Tom Lewis sits in 120th position despite a missed cut at the PGA Championship, having finished runner-up in Memphis the week before, while Tommy Fleetwood (85th) and Graeme McDowell (108th) will be looking to make big moves up the standings ahead of the play-offs.
Four-time major champion Brooks Koepka (92nd) is one of three players from the world's top 10 in the field, his sixth event in as many weeks, with former FedExCup winners Justin Rose and Jordan Spieth - 103rd and 94th in the standings - also in action.
Only the top-125 in the FedExCup standings are eligible to tee it up at the Northern Trust next week, the first of three play-off events, with the top-70 then progressing to the BMW Championship from August 27-30.
The PGA Tour season then reaches a climax at the Tour Championship from September 4-7, where all 30 players in the field have a chance of winning the FedExCup and the $15 million jackpot.
Watch the Wyndham Championship throughout the week live on Sky Sports. Live coverage begins on Thursday with Featured Groups from 6pm on Sky Sports Golf!