Wednesday 25 November 2015 17:24, UK
Wembley Stadium is all set to enter its tenth year of hosting NFL matches after the announcement of the 2016 International Series matches.
The relationship has only grown, and there's plenty more drama on the way.
With more great action to look forward to, we've recapped the NFL's top five matches under London's famous arch...
So this wasn't a classic game but being the first regular season encounter outside of the United States makes it special.
Over 80,000 packed into Wembley, a figure that has been matched in all bar one of the subsequent games, to see Eli Manning, then aged 26 and settled into his boots three years after the Giants made him their No. 1 Draft pick, run home a second quarter, match-winning touchdown.
As well as Manning's 10-yard TD run, Scottish-born kicker Lawrence Tynes contributed seven points and London-born Giants defensive end Osi Umenyiora also featured. He spoke for just about everyone when he said: "It was a bad game, but we had a good time."
The occasion was not spoiled by a torrential downpour or Manning's difficulties, as the quarterback threw for just eight of 22 attempts for 59 yards. Hardly the stats you would expect from a QB that would go on to be Super Bowl XLII MVP as the Giants upset the odds against the New England Patriots.
The Dolphins endured an eighth, straight defeat, continuing their worst start in 42 years, but talking points afterwards surrounded the suitability of the Wembley turf and the ramifications of its demise throughout the game.
After the previous low-scoring mudfest, the NFL returned in some style. Drew Brees and Philip Rivers engaging in a shootout that will live long in the memory.
Both threw for over 300 yards and three touchdown passes apiece as the second NFL regular-season game in London went down to the wire.
After Brees had done the damage against his former team-mates, the Chargers came from 37-20 down to set up a frantic finale. But Rivers' last-gasp throw from 50 yards was broken up by the Saints defence who held on for 37-32 win.
Tom Brady, the NFL pin-up boy six years ago, and who has only increased his status since, dominated the third game on English soil as the sight of home-grown fans marching down Wembley Way clad in American gear became familiar.
Brady made up for two early interceptions by throwing for 308 yards and three touchdowns, condemning the Bucs to a 11th defeat on the trot which extended their season's numbers to 0-7.
The pitch held up to the challenge, and while the Patriots made the occasion one-sided, the Bucs were left wondering why they surrendered a home match for the chance to cross the Atlantic.
The Lions staged a remarkable comeback to underline what history may remember as the most memorable NFL game that Wembley has ever hosted.
The Falcons led 21-0 at half-time after three touchdowns but the Lions roared back in style. Matthew Stafford, their quarterback, threw two touchdown passes and Matt Prater kicked a pair of field goals to give Detroit a fighting chance. With the seconds dwindling, Prater kicked from 48 yards to win the game for the Lions.
It was a case of third-time lucky for the Jacksonville Jaguars on English soil after a dramatic finish saw them overcame the Bills 34-31 in front of 84,021 at Wembley. If the Lions Falcons isn't your favourite Wembley game, then this one surely is.
Errors from Bills quarterback EJ Manuel allowed Chris Clemons and Telvin Smith to help the Jags take a 27-3 first-half lead.
The Bills bounced back with 28 unanswered points and lead 30-27 late on until Allen Hurns' diving touchdown with just over two minutes left on the clock gave the Jags their first Wembley win.
You can see Philadelphia Eagles @ Detroit Lions, Carolina Panthers @ Dallas Cowboys and Chicago Bears @ Green Bay Packers live on Sky Sports 1 HD from 5pm this Thanksgiving.
