Heavyweight star Luis Ortiz will top the bill on a night that sees Jamie McDonnell and Stephen Smith in world title fights and Martin Murray looking for revenge in Monte Carlo next month, live on Sky Sports.
Ortiz, nicknamed 'King Kong', tackles Malik Scott in his first fight as a Matchroom fighter at the Salle des Etoiles, Monte Carlo, on November 12.
McDonnell will make the fifth defence of his WBA bantamweight world title against Liborio Solis.
Smith will get a second chance to be crowned a super-featherweight world champion as he challenges WBA holder Jason Sosa, while Murray will go in against Arthur Abraham after losing a controversial split decision when he challenged the former WBO super-middleweight holder last November.
"It is an absolute honour to bring this huge night of world championship boxing to Monaco," said promoter Eddie Hearn.
"It's been a wonderful few years for British boxing but to showcase this great sport in such a high quality environment is very exciting. This is going to be the most high profile fight night of the year and we are looking forward to putting on an exceptional night of boxing for Monte Carlo, fans and all of our international broadcasters."
Ortiz, who has won 22 of his 25 fights by knockout, takes on the experienced Scott - whose last loss came in a WBC world title eliminator against Deontay Wilder - with the WBA Intercontinental belt on the line.
McDonnell, who stopped Fernando Vargas in nine rounds in April in his only fight this year, defends his crown against Solis, who is trying to become a two-weight world champion after ruling the super-flyweight division.
And Smith, one of the famous four boxing brothers from Liverpool, has landed a second world title shot, having lost his first attempt against experienced and awkward IBF holder Jose Pedraza in April. Opponent Sosa will be defending his WBA title for the first time after taking it from Javier Fortuna in Beijing in June 2016.
There's also a tasty rematch on the bill as Murray looks to avenge his loss to Abraham as the pair clash for the WBO International super-middleweight belt. The St Helens man has previously fought at the Salle des Etoiles, losing to knockout specialist Gennady Golovkin in 11 rounds in February 2015.