The Detroit Lions had a 100-yard rusher for the first time in 71 games as they overcame the New England Patriots on Sunday night.
Drew Brees ran in for an overtime touchdown that lifted the New Orleans Saints to victory over NFC South rivals Atlanta Falcons.
San Francisco 49ers quarterback Jimmy Garoppolo suffered a possible season-ending knee injury in defeat to the Kansas City Chiefs.
Jared Goff passed for 354 yards and three touchdowns, leading the Rams to victory over the Chargers in the Los Angeles derby.
Ryan Fitzpatrick has starred for the Tampa Bay Buccaneers through the first two weeks of the season, but how long can he keep his run going?
Carolina Panthers defensive end Efe Obada enjoyed a dream start to his NFL career with an interception and a sack.
The Buffalo Bills stunned the Minnesota Vikings, with rookie quarterback Josh Allen throwing a touchdown and running in for two more.
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The Chargers and Rams face off for the first time in their adopted home of Los Angeles this Sunday, live on Sky Sports Action from 9.05pm.
Fantasy analyst expert Adam Rank takes on the NFL Challenge, picking his team for Week Three...
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Neil Reynolds and Jeff Reinebold make their Week Three picks as they go head to head in Sky Sports' weekly NFL predictions...
Neil Reynolds picks six storylines from Week Two, including Patrick Mahomes' six TDs, some more 'Fitzmagic' and a call with Andrew Luck...
Neil Reynolds and Jeff Reinebold make their Week Two picks as they go head to head in Sky Sports' weekly NFL predictions...
Neil Reynolds reflects on six storylines from the opening weekend in the NFL, including Aaron Rodgers' stunning comeback.
We hear from the Around the NFL podcast team and get their take on Week Three in the NFL.
The guys at Pro Football Focus run through the top rated players from Week Three in the NFL.
The Around the NFL podcast team pick out the NFL storylines that are going under the radar ahead of Week Three.
ProFootballTalk journalist Peter King reflects on the main talking points from Week Two in the NFL.
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