Lens ended a difficult campaign on a high after an early Pablo Chavarria goal earned them a 1-0 home victory over Nantes.
Liverpool give U21s more game time than Premier League rivals but top flight lags behind Europe.
Nice confirmed their Ligue 1 status, but they did it the hard way, coming from behind to beat bottom club Lens.
Marseille kept their hopes of Champions League qualification alive after a late comeback saw them beat Monaco 2-1.
A stoppage-time winner from Anthony Mounier was enough to give Montpellier a 1-0 win over 10-man Lens.
Lens' relegation from Ligue 1 was sealed on Sunday afternoon as they slumped to a 3-1 loss at derby rivals Lille.
Lyon moved back to the top of Ligue 1 with victory at Reims, while there were wins for Monaco and St Etienne.
Yannick Carrasco's clinical 36th-minute opener paved the way for Monaco to retain third place with a 3-0 win at Lens
Paris Saint-Germain bounced back from their Champions League defeat to Barcelona to move top of Ligue 1 after a 3-1 victory over Nice.
Lens' stay in Ligue 1 looks even more precarious after they were beaten 3-1 by relegation rivals Metz.
Franck Tabanou scored the winner as Saint-Etienne beat Nantes 1-0 on Sunday, while Lille and Rennes also claimed victories.
Strugglers Lens and Lorient played out a frustrating goalless draw at Stade De La Licorne in Ligue 1 on Sunday.
An injury-time goal by Nicolas Maurice-Belay gave Bordeaux a 2-1 home victory against relegation-threatened Lens.
Nicolas Maurice-Belay's stoppage-time goal saw Bordeaux claim a last gasp 2-1 win over rock-bottom Lens on Sunday.
Michy Batshuayi scored twice as Marseille claimed a 4-0 win at Lens.
Marseille maintained their Ligue 1 title challenge with a 4-0 victory at Lens on Sunday.
Ivory Coast winger Max-Alain Gradel scored for the fourth straight match as Saint-Etienne secured a 3-2 win at struggling Metz.
Lens gave their Ligue 1 survival hopes a shot in the arm as they ended a nine-game winless run by beating Toulouse.
Paris St Germain responded to Marseille's 6-1 win with a thumping 4-1 victory of their own against Lens.
Lens' miserable run of form continued as they lost 1-0 at home to Rennes.