West Ham gave Bundesliga champions Bayer Leverkusen a huge scare before Jeremie Frimpong's late goal earned a 3-1 aggregate win to reach the Europa League semi-finals.
Liverpool were eliminated from the Europa League despite beating Atalanta 1-0 in Bergamo, with all the damage done in the first leg, falling to a 3-1 aggregate score.
Aston Villa have reached the Europa Conference League semi-finals with a dramatic shootout win at Lille, winning 4-3 on penalties after rescuing a 3-3 draw on aggregate.
Holders Manchester City are out of the Champions League following a penalty shoot-out defeat to Real Madrid in an epic encounter at the Etihad Stadium.
A bullet header from Joshua Kimmich saw Bayern Munich win 1-0 in their Champions League quarter-final second leg, knocking Arsenal out of the competition.
Rangers' Scottish Premiership title hopes suffer another blow as a goalless draw at Dundee leaves them three points behind Celtic.
Chelsea put a difficult few weeks behind them to leapfrog Man City at the top of the WSL after a 3-0 win over Aston Villa on Wednesday night.
Borussia Dortmund beat Atletico Madrid 4-2 on the night and 5-4 on aggregate to set up a mouth-watering Champions League semi-final with Paris Saint-Germain.
Luis Enrique returned to Barcelona to knock his former club out of the Champions League as Kylian Mbappe inspired PSG to a pulsating comeback victory.
Four-goal Cole Palmer starred as Chelsea hammered sorry Everton 6-0 on Monday Night Football to move to within three points of the European qualifying spots.
Arsenal's Premier League title hopes were dealt a huge blow by Unai Emery, who returned to stun his former club as Aston Villa claimed a 2-0 win at the Emirates.
Manchester United advanced to an FA Cup final against Tottenham after holding out for an historic 2-1 victory over holders Chelsea at Leigh Sports Village.
Liverpool suffered a major blow to their Premier League title hopes as they were shockingly beaten 1-0 by Crystal Palace at Anfield.
Andreas Pereira's well-taken double either side of half-time saw Fulham win 2-0 at a lackluster West Ham as Marco Silva's side got back to winning ways in the top flight.
Martha Thomas came off the bench to score an extra-time winner to send Tottenham into their first Women's FA Cup final, leaving Leicester heartbroken.
Ross County delivered a body blow to Rangers' Scottish Premiership title hopes with a stunning 3-2 victory, their first-ever win over the Ibrox side.
Bruno Fernandes twice hauled Man Utd level at Bournemouth as his side grabbed a barely-deserved 2-2 draw that further decreases their Champions League hopes.
Nottingham Forest were held to an entertaining 2-2 draw with Midlands rivals Wolves at the City Ground, leaving them one point better off than relegation rivals Luton.
Manchester City moved ahead of Arsenal and Liverpool to the top of the Premier League with a routine 5-1 victory over Luton.
Another Aro Muric mistake cost Burnley a precious victory in their bid for Premier League survival, with Brighton escaping from Turf Moor with a 1-1 draw.