Lautaro Martinez's late winner stretched Inter's winning run to eight games, while Cristiano Ronaldo answered his critics with a perfect hat-trick.
Zlatan Ibrahimovic made a winning return to the AC Milan team as his quickfire double won the Milan derby, while Real Madrid and Barcelona suffered shock defeats.
Benjamin Nivet scored a last-minute winner as Ligue 2 Troyes seized the upper hand in the first leg of their play-off clash with Lorient.
Marseille secured Europa League football while Caen dramatically kept themselves in Ligue 1 in the final minutes of the season.
Monaco won 3-0 at Nancy to end the day as they began it, three points clear at the Ligue 1 summit.
Former Newcastle midfielder Sylvain Marveaux was among four people arrested in France on Wednesday as part of the tax evasion probe.
| # | Team | Pl | GD | Pts |
|---|---|---|---|---|
| 14 | Reims | 38 | -8 | 42 |
| 15 | Strasbourg | 38 | -9 | 42 |
| 16 | Lorient | 38 | -18 | 42 |
| 17 | Brest | 38 | -16 | 41 |
| 18 | Nantes | 38 | -8 | 40 |
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