Bayer Leverkusen moved up to fifth place in the Bundesliga after claiming their fourth straight win with a 2-0 success against Fortuna Dusseldorf.
Carlo Ancelotti saw his Napoli team take a strong grip on their Europa League last-32 tie against FC Zurich, winning 3-1 in Switzerland.
Bayern Munich crashed to a shock 3-1 defeat at Bayer Leverkusen on Saturday, while Borussia Dortmund drew with Frankfurt.
Borussia Dortmund opened a nine-point lead over Bayern Munich at the top of the Bundesliga table with a 5-1 rout of strugglers Hanover on Saturday.
Borussia Dortmund restored their six-point lead at the top of the Bundesliga with a 1-0 victory at RB Leipzig.
Bayer Leverkusen have appointed former Ajax and Borussia Dortmund head coach Peter Bosz as their new boss, replacing the sacked Heiko Herrlich.
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