Lionel Messi celebrated his return to competition following the World Cup by scoring a second-half goal as Paris St Germain extended their Ligue 1 lead to six points.
Tammy Abraham's penalty more than nine minutes into stoppage time ended Roma’s winless run as Jose Mourinho's scraped a 1-0 victory at 10-man Spezia in Serie A.
Karim Benzema's 83rd-minute goal was enough for Real Madrid to extend their lead at the top of La Liga to nine points with a 1-0 win at Rayo Vallecano.
Tanguy Ndombele has returned to Lyon on loan to bring an end to his disappointing spell at Tottenham.
Valencia shook off the late red card for Jose Gaya to hold La Liga title challengers Sevilla to a 1-1 draw.
Bayern Munich extended their Bundesliga lead to six points with Jamal Musiala on target as they beat Mainz 2-1, while Borussia Dortmund were held by Bochum.
Memphis Depay and Philippe Coutinho scored late on at Villarreal as Barcelona won 3-1 to finally end their winless streak away from home under new coach Xavi.
Mauricio Pochettino has defended his decision to sub off Lionel Messi in PSG's late 2-1 win over Lyon on Sunday, while Real Madrid brilliantly fought back at Valencia.