Lautaro Martinez's late winner stretched Inter's winning run to eight games, while Cristiano Ronaldo answered his critics with a perfect hat-trick.
Angel Di Maria and Christopher Nkunku scored second-half goals as Paris St Germain won 2-0 at Troyes to go 14 points clear at the top of Ligue 1.
Marseille secured Europa League football while Caen dramatically kept themselves in Ligue 1 in the final minutes of the season.
Ligue 1 leaders Nice crashed out in the last 64 of the French Cup on Sunday after a 2-1 defeat at struggling Lorient.
Crystal Palace are bottom of the Europe-wide form table - and only one Premier League team makes the top 10.
Lens ended a difficult campaign on a high after an early Pablo Chavarria goal earned them a 1-0 home victory over Nantes.
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