Memphis Depay scored from near the halfway line as Lyon rode their luck early before crushing Toulouse 4-0 on Sunday.
Monaco saw off Nantes 4-0 to restore their three-point lead in Ligue 1, as Marseille beat Lorient and Lille drew at Toulouse.
Ligue 1 leaders Monaco returned to winning ways with a 2-1 triumph over Guingamp to restore their three-point lead.
Nice's title hopes suffered another blow with more dropped points in a 2-2 draw at Rennes.
Yassine Benzia scored twice against his old club as Lille ran out 2-1 winners at Lyon in Ligue 1 on Saturday.
Gabriel Boschilia and Valere Germain both struck twice as Monaco beat Lorient 4-0 to move two points clear at the top of Ligue 1.
Lorient moved off the bottom of the table after a 3-1 win over Guingamp, while there were wins for Nancy and Nates.
Ligue 1 leaders Nice crashed out in the last 64 of the French Cup on Sunday after a 2-1 defeat at struggling Lorient.
PSG slumped to their fourth Ligue 1 defeat of the season as they were beaten 2-1 at Guingamp while Bastia continued their resurgence.
Monaco moved back to the top of Ligue 1 on goal difference after a late strike from Frederic Sammaritano earned Dijon a 1-1 draw.
Monaco kept up their outstanding recent form as Valere Germain scored twice in a 4-0 win over Marseille on Saturday.
Radamel Falcao was on target as Monaco went top of Ligue 1 with a 3-0 win at bottom side Lorient while Lyon went fourth.
Monaco trimmed Nice's lead at the top of Ligue 1 to three points as Leonardo Jardim's side thrashed Nancy 6-0.
Monaco missed the chance to close the gap on Ligue 1 leaders Nice while Alexandre Lacazette scored twice for Lyon.
Laurent Koscielny says he will see out his career with Arsenal or Lorient
Lyon's alarming slump in form continued on Saturday as they lost 3-1 at home to Guingamp.
Paris Saint-Germain claimed a share of second place in Ligue 1 with a 2-1 win at Nancy.
Mario Balotelli scored a late winner and was then sent off as Nice returned to the top of Ligue 1 with a 2-1 win over Lorient.
Monaco moved to the top of Ligue 1 after coming from behind to beat Angers 2-1 while Lyon were upset by Lorient.
Mario Balotelli scored twice as Nice beat Monaco 4-0 to go top of Ligue 1, while there were also wins for Lyon and Bordeaux.