New England's regular season winning run came to a crushing end but the Dallas Cowboys remain one of six unbeaten teams.
Eagles dare to beat Pittsburgh as Jaguars kick past Colts
The Miami Dolphins broke their duck for the season in sensational fashion - bringing to an end New England's record winning run in the process.
Ronnie Brown ran for four touchdowns and threw for another as the Patriots lost for the first time in 22 regular season games.
Elsewhere, the Indianapolis Colts are still yet to win at their new stadium after losing late to Jacksonville, while the New York Giants and Tampa Bay needed field goals in overtime to clinch victory.
The Dallas Cowboys maintained their perfect record with an impressive success on the road in Green Bay.
They are one of six teams still to be beaten this year, including a pair of surprise packages - the Tennessee Titans and the Buffalo Bills.
New England Patriots 13-38 Miami Dolphins
New England's record winning run came to a shuddering halt as Ronnie Brown ran all over them at Gillette Stadium.
The Patriots had previously not lost in their last 21 regular season outings but were soundly beaten 38-13 by the Dolphins, who were also the last team to get the better of Bill Belichick's side outside of the play-offs.
Brown was the star turn for the hosts, rushing for 113 yards on 17 carries and four touchdowns - a record for the franchise. He also threw for another, hitting tight end Anthony Fasano from 19 yards out on a trick play.
New England's only score came when Jabar Gaffney caught a five-yard pass from Matt Cassel, their other points coming courtesy of two Stephen Gostkowski field goals.
Washington Redskins 24-17 Arizona Cardinals
The Washington Redskins ended Arizona's unbeaten start to the new campaign with a 24-17 success on the road.
In a see-saw battle the visitors took a crucial lead when Carlos Rogers intercepted Cardinals quarterback Kurt Warner early in the fourth quarter.
The turnover led to Warner's opposite number Jason Campbell, who is still yet to throw an interception this season, finding Santana Moss for the winning score.
Until then Arizona, who never led throughout the game, had always managed to peg back their opponents, Warner finding both his star receivers, Anquan Boldin and Larry Fitgerald, in the end zone.
Carolina Panthers 10-20 Minnesota Vikings
Gus Frerotte marked his first start of the season under centre for Minnesota by leading them to a 20-10 win over the Carolina Panthers.
The quarterback, taking over from the benched Tarvaris Jackson, threw a touchdown to Visanthe Shiancoe in the third quarter to make it 17-10.
By then Antonio Winfield had already returned a fumble by Carolina quarterback Jake Delhomme to the end zone after the Panthers had raced out to a 10-0 lead thanks to a John Kasay field goal and a two-yard TD run by Jonathan Stewart.
Ryan Longwell's 32-yard field goal secured the win for the Vikings, whose defence forced two turnovers and only gave up 204 yards.
Tennessee Titans 31-12 Houston Texans
The Titans maintained their perfect record with a comprehensive 31-12 result on the road in Houston.
LenDale White ran in two touchdowns to help Tennessee win a game that included five turnovers, one of which was returned 99 yards for a score by Titans' Cortland Finnegan in the fourth quarter.
By then the result was already assured, White's double being added to by a score for Bo Scaife and a Rob Bironas field goal.
Houston's only trip to the end zone came on a six-yard run by Steve Slaton. Kris Brown kicked two field goals in the first quarter.
Oakland Raiders 23-24 Buffalo Bills
Buffalo moved to 3-0 for the first time since 1992 thanks to a fourth-quarter comeback that climaxed with Rian Lindell's game-wining field goal as time expired.
The Bills had trailed 16-7 after three quarters, JaMarcus Russell running in from a yard out to get Oakland's only touchdown after a trio of field goals from Sebastian Janikowski.
However the home team rallied in sensational fashion, Marshawn Lynch scoring for the second time on the day, although the Raiders briefly replied when Russell hit Johnnie Lee Higgins.
Even still Buffalo continued to come back, Trent Edwards finding Roscoe Parrish to close the deficit to two before Lindell held his nerve right at the death.
Tampa Bay Buccaneers 27-24 Chicago Bears
Matt Bryant's 21-yard field goal in overtime settled an offensive slug-fest at Soldier Field in Tampa Bay's favour.
Quarterback Brian Griese set up his kicker with an excellent drive as he threw for a total of 407 yards and two touchdowns, although he was intercepted three times.
It was his one-yard throw to tight end Jerramy Stevens that knotted up the score seven seconds from the end of regulation.
The Bears had looked set to hang on until then, Kyle Orton throwing scoring passes to Matt Forte and Brandon Lloyd to help them overturn a 14-9 half-time deficit.
Cincinnati Bengals 23-26 New York Giants
The Cincinnati Bengals are still waiting for their first win after John Carney's field goal in over time made sure the New York Giants remained perfect.
The kicker chipped over from 22 yards to end the game having already landed shots from 24, 26 and 46 yards in regulation.
New York's touchdowns came from Brandon Jacobs on the ground and Kevin Boss through the air, though they were never able to break clear from the Bengals.
T.J. Houshmandzadeh caught a touchdown pass, one of 12 catches for the receiver for 146 yards. Shayne Graham slotted over three field goals, his last levelling the scores as time expired.
Kansas City Chiefs 14-38 Atlanta Falcons
Michael Turner scored three touchdowns on the ground as Atlanta heaped more misery on the winless Kansas City Chiefs.
The running back helped the Falcons score the first 24 points of the contest, Roddy White managing to also get into the end zone thanks to a 70-yard pass from rookie quarterback Matt Ryan.
The Chiefs replied with efforts from receiver Dwayne Bowe and tail back Larry Johnson, but were never really in contention.
The Falcons sealed the result when Chris Houston returned an interception 10 yards in the fourth quarter.
Detroit Lions 13-31 San Francisco 49ers
Frank Gore rushed for 130 yards and a touchdown as San Francisco dominated Detroit to leave the Lions still searching for their first win.
The running back's four-yard effort was sandwiched in between touchdown throws by quarterback J.T. O'Sullivan. Allen Rossum also scored on the ground from one-yard out.
Victory was particularly sweet for 49ers' offensive coordinator Mike Martz, who saw his new team hammer his former employers.
Detroit did manage a touchdown when Jon Kitna hit Rudi Johnson from 34 yards in the fourth quarter, though by then they were already well out of contention.
St Louis Rams 13-37 Seattle Seahawks
Seattle demolished their NFC West rivals St Louis 37-13 on home soil to claim their first victory and leave the Rams in a rut at 0-3.
Julius Jones ran for 140 yards and a touchdown on 22 carries, and TJ Duckett combined for 245 yards on the ground for the Seahawks, who with massive injury problems at receiver decided to keep it on the ground.
Duckett scored twice from close range while quarterback Matt Hasselbeck did manage one TD through the air, hitting undrafted rookie Michael Bumpus from 10 yards out.
St Louis - who have the worst offence and defence in the NFL - had six points in the first half thanks to two Josh Brown field goals before Marc Bulger found Dane Looker in the end zone in the third quarter.
New Orleans Saints 32-34 Denver Broncos
For the second successive week the Denver Broncos were involved in a high-scoring thriller at Mile High Stadium, and once again they came out on top.
A week after destroying the San Diego Chargers receiver Brandon Marshall enjoyed another stellar game, finishing with 155 yards on six catches as well as a touchdown in the first quarter.
Quarterback Jay Cutler also hit Nate Jackson in the end zone while Michael Pittman scored on the ground, though the Saints could have won it had Martin Gramatica not missed a 43-yard field goal inside the final two minutes.
Running backs Reggie Bush and Pierre Thomas both managed two touchdowns apiece for New Orleans who forced a saftey at the end of the first half when Charles Grant tackled Andre Hall in the end zone.
Pittsburgh Steelers 6-15 Philadelphia Eagles
With their offence hurting, Philadelphia's defence stepped up to the plate to help the Eagles get the better of the Pittsburgh Steelers.
The home team sacked Steelers quarterback Ben Roethlisberger eight times and forced three turnovers as they held their opponents to just two Jeff Reed field goals.
Despite seeing running back Brian Westbrook limp out of action in the first half, Philadelphia found an able replacement in Correll Buckhalter, who managed the only touchdown on a 20-yard pass from Donovan Mcnabb.
Jacksonville Jaguars 23-21 Indianapolis Colts
Josh Scobee kicked a field goal from 51 yards in the closing seconds as the Jaguars made sure Indianapolis were still left searching for a first win at their new Lucas Oil Stadium.
The kicker had already landed chip shots from 26 and 21 yards while Jacksonville managed touchdowns from Maurice Jones-Drew, on a six-yard run, and Rashean Mathis, who picked off Peyton Manning and returned it all the way.
The Colts had taken the lead when Manning combined with Marvin Harrison before Joseph Addai managed two touchdowns on the grounbd.
His second effort with just over a minute to play seemed to have clinched it for the hosts, only for Scobee to step up and win it for the Jags. Both teams now have 1-2 records for the year.
Cleveland Browns 10-28 Baltimore Ravens
Baltimore scored 21 points in the third quarter to beat the Browns, who are now winless after the first three weeks.
Le'Ron McClain scored his first two NFL touchdowns on a pair of one-yard runs in between Ed Reed returning an interception, one of three thrown by Cleveland QB Derek Anderson, all the way to the end zone.
Anderson did manage a 19-yard scoring pass to Jerome Harrison in the first quarter but the Ravens only allowed a Phil Dawson field goal after that, holding their opponents scoreless in the second half.
Dallas Cowboys 27-16 Green Bay Packers
Marion Barber ran for a career-high 142 yards as the Cowboys charged to 3-0, despite a quiet day for Terrell Owens, ending Green Bay's unbeaten start in the process.
The running back scored on a two-yard run to cap a fine personal display, while rookie Felix Jones also went in on the ground, his 60-yard effort meaning he has now managed touchdowns in his first three NFL games.
When quarterback Tony Romo found Miles Austin with a 52-yard pass, Dallas were 27-9 ahead having held the Packers to a trio of field goals from Mason Crosby.
Green Bay did attempt to rally in the fourth quarter, though Aaron Rodgers' one-yard run with just over two minutes to play was no more than a late consolation.
