David Neres scored twice as Ajax moved a step closer to Champions League qualification with a 4-1 win at home to VVV-Venlo.
PSV Eindhoven secured their 24th Eredivisie title after beating Ajax 3-0 on Sunday.
Ajax celebrated their 118th birthday in memorable fashion with a 5-2 thrashing of Sparta Rotterdam.
Ajax's hopes of winning the Eredivisie title suffered another setback as they were beaten 3-2 at Vitesse Arnhem on Sunday.
AZ Alkmaar kept the pressure on second-placed Ajax by coming from behind to beat the Eredivisie's bottom club Sparta Rotterdam 2-1.
Ajax reduced the gap to Eredivisie leaders PSV to seven points following a hard-fought 2-1 victory against FC Twente.
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