Davinson Sanchez and Kasper Dolberg both scored twice as Ajax beat Zwolle 5-1 while PSV won at Excelsior.
Groningen thrashed Utrecht 5-1 on Friday to earn their first win of the season in the Eredivisie.
Feyenoord maintained their perfect start to the season, while there were wins for Ajax and Go Ahead Eagles in the Eredivisie on Sunday.
PSV Eindhoven surrendered their 100 per cent record in disappointing fashion after being held to a 0-0 draw at home to Groningen.
Feyenoord continued their perfect start to the season and returned to the top of the Eredivisie with a 1-0 win at Heracles Almelo.
Ajax were held to a draw by Roda JC in a four-goal thriller on Saturday, while Vitesse lost at home to ADO Den Haag.