Wout Weghorst scored and was later sent off as AZ Alkmaar held on for a 3-2 comeback victory against struggling Willem II.
Hirving Lozano and Jurgen Locadia each scored twice as PSV Eindhoven restored their five-point lead at the top of the Eredivisie.
Kasper Dolberg scored twice as Ajax beat rivals Feyenoord 4-1 in the Eredivisie on Sunday.
Feyenoord won 4-0 at AZ to climb up to second, Ajax beat Heerenveen by the same scoreline while Vitesse and Utrecht drew 1-1.
Jurgen Locadia scored four goals as PSV Eindhoven trounced FC Utrecht 7-1 to climb to the top of the Eredivisie table.
Sparta Rotterdam 'keeper Roy Kortsmit went from hero to villain and back again as he saved the same penalty twice against AZ Alkmaar.
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