Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Diego Perotti struck at the death as Roma handed Francesco Totti a farewell to remember with a 3-2 win home win over Genoa.
Juventus clinched a record sixth straight Serie A title with a 3-0 win over Crotone in the penultimate round on Sunday.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.