Crotone beat Lazio 3-1 on the final day to ensure survival, as Empoli went down after losing at already-relegated Palermo.
Diego Perotti struck at the death as Roma handed Francesco Totti a farewell to remember with a 3-2 win home win over Genoa.
Juventus clinched a record sixth straight Serie A title with a 3-0 win over Crotone in the penultimate round on Sunday.
Napoli took advantage of Roma's derby defeat to close to within one point of second place in Serie A with victory over Inter Milan.
Juventus took a giant leap towards securing an historic sixth consecutive Serie A title by thrashing hapless Genoa 4-0 in Turin.
Juve extended their lead at the top of Serie A after beating Pescara 2-0 to strengthen their grip on a sixth straight Scudetto title.
Napoli all but locked Lazio out of third place by opening a seven-point gap on their rivals with a 3-0 victory on Sunday.
The latest transfer talk from around Europe as Man Utd reportedly line up a £51m offer for Inter Milan winger Ivan Perisic.
Juventus' Gonzalo Higuain failed to score on his long-awaited return to Napoli as the game ended 1-1, while Crotone beat Chievo.
Matias Fernandez's first goal for AC Milan was enough to earn them a 1-0 home win against Serie A rivals Genoa.
Sampdoria scored a historic 1-0 derby victory against Genoa in Serie A's only match on Saturday.
Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Roma closed the gap on Serie A leaders Juventus to seven points with a 3-1 win away to Inter Milan at San Siro.
Napoli moved up to second in the Serie A table with a 2-0 home victory over strugglers Genoa.
Juan Cuadrado's thunderbolt gave Juventus 1-0 home win over Inter Milan on Sunday, as Sampdoria beat AC Milan and Lazio hit six.
Gonzalo Higuain reached 15 goals for the Serie A season as Juventus reinforced their position as leaders with a 2-0 win over Sassuolo.
Paulo Dybala and Gonzalo Higuain scored as Serie A leaders Juventus beat fourth-placed Lazio 2-0 on Sunday.
Fiorentina put a dent in Juventus' title charge with a 2-1 win at the Stadio Artemio Franchi.
Serie A leaders Juventus returned from their winter break with a 3-0 dismantling of Bologna on Sunday night.
Adel Taarabt has joined Genoa on an 18-month loan in a bid to rejuvenate his career.