Fernando Bernardeschi scored the only goal as Juventus kept Serie A leaders Napoli in their sights with a 1-0 win over Cagliari.
Roma's bid to break into Serie A's top three was thwarted in part by two video assistant referee decisions as they drew 1-1 against Sassuolo.
Marek Hamsik surpassed Diego Maradona's long-standing goalscoring record for Napoli as the Azzurri pulled clear at the top of Serie A.
Reigning champions Juventus stormed back into second place in the Serie A table, while AC Milan's imploding season took another turn for the worse.
Serie A leaders Inter Milan needed a penalty-shoot-out to beat Serie C side Pordenone in the Coppa Italia on Tuesday.
Jakub Jankto scored twice as Udinese won 3-0 at the Stadio Ezio Scida to condemn Crotone to a third straight Serie A defeat.
Juventus returned to winning ways with a comfortable home victory on Sunday while Napoli moved back to the top of Serie A.
Massimiliano Allegri's decision to rest two key players backfired as Juventus lost 3-2 at Sampdoria.
Second-half goals from Gonzalo Higuain and Juan Cuadrado meant Juventus came from behind to inflict a 12th straight Serie A defeat on struggling Benevento.
Gaston Ramirez and Fabio Quagliarella scored as Sampdoria secured a 2-0 win at Genoa in the Derby della Lanterna on Saturday.
Unbeaten Napoli moved three points clear at the top of Serie A with a 3-1 win against Sassuolo at Stadio San Paolo.
AC Milan and Juventus swept to comfortable victories on a night in Serie A that will be remembered for off-pitch reasons.
Sami Khedira scored a first career hat-trick as 10-man Juventus recovered to trounce Udinese 6-2 at the Dacia Arena.
Sampdoria came from behind to record a 3-1 victory over Atalanta at the Stadio Luigi Ferraris on Sunday.
Manchester City are interested in signing Roma's 21-year-old midfielder Lorenzo Pellegrini, according to Sky in Italy.
Udinese ended Sampdoria's unbeaten Serie A start with a 4-0 victory at Friuli, where midfielder Edgar Barreto was sent off.
Former QPR midfielder Adel Taarabt received a straight red card as nine-man Genoa lost 1-0 to Inter Milan.
Ciro Immobile scored a hat-trick as Lazio humbled new-look AC Milan 4-1 at the Stadio Olimpico on Sunday.
Paulo Dybala's hat-trick helped Juventus overcome an early collapse as the Serie A champions fought back to beat Genoa.
The latest from the European newspapers as PSG reportedly offer striker Edinson Cavani to Real Madrid.
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