Reigning champions Juventus stormed back into second place in the Serie A table, while AC Milan's imploding season took another turn for the worse.
AC Milan got their first win under manager Gennaro Gattuso with a 3-0 victory over Hellas Verona in Coppa Italia.
Gennaro Gattuso recorded his first win as AC Milan head coach with a 2-1 Serie A victory at home to Bologna.
Ivan Perisic scored a hat-trick as Inter moved top of the table with a 5-0 win over Chievo.
Juventus returned to winning ways with a comfortable home victory on Sunday while Napoli moved back to the top of Serie A.
Massimiliano Allegri's decision to rest two key players backfired as Juventus lost 3-2 at Sampdoria.
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