Chelsea loanee Juan Cuadrado was the hero for Juventus on a busy day of Serie A action, with Roma and Napoli also victorious.
Mauro Icardi and Ever Banega scored hat-tricks as Inter Milan thrashed Atalanta 7-1 in Serie A on Sunday.
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Juventus now lead Serie A by eight points after drawing 1-1 at Udinese on Sunday, while Lazio and Inter Milan both claimed away wins.
Lyon cruised through to the last 16 of the Europa League with a thumping 11-2 aggregate win over AZ Alkmaar.
Edin Dzeko hit a 21-minute hat-trick as Roma took a 4-0 first-leg advantage in their Europa League last-32 tie against Villarreal.