ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
David Neres scored twice as Ajax moved a step closer to Champions League qualification with a 4-1 win at home to VVV-Venlo.
PSV Eindhoven secured their 24th Eredivisie title after beating Ajax 3-0 on Sunday.
PSV Eindhoven maintained their dominance of the Eredivisie with a 5-1 win over NAC Breda on Saturday.
Manchester City are closing in on the Premier League title, but who else is set for glory - and misery - around Europe?
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