ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Bottom club FC Twente boosted their Eredivisie survival hopes with a 2-0 home win over PEC Zwolle.
Bryan Linssen scored twice in the second half as Vitesse won 7-0 against 10-man Sparta Rotterdam on Saturday.
Eredivisie leaders PSV Eindhoven returned to winning ways on Saturday evening with a 3-0 home victory over VVV Venlo.
AZ Alkmaar kept the pressure on second-placed Ajax by coming from behind to beat the Eredivisie's bottom club Sparta Rotterdam 2-1.
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