ADO Den Haag and Heerenveen will join Vitesse and Utrecht in the play-offs for the last Europa League spot despite mixed fortunes on the final day.
Former Eredivisie champions FC Twente have been relegated from the league after a thumping 5-0 defeat at Vitesse on Sunday.
Bottom club FC Twente boosted their Eredivisie survival hopes with a 2-0 home win over PEC Zwolle.
Bryan Linssen scored twice in the second half as Vitesse won 7-0 against 10-man Sparta Rotterdam on Saturday.
Eredivisie leaders PSV Eindhoven returned to winning ways on Saturday evening with a 3-0 home victory over VVV Venlo.
AZ Alkmaar kept the pressure on second-placed Ajax by coming from behind to beat the Eredivisie's bottom club Sparta Rotterdam 2-1.
Steven Bergwijn scored twice as leaders PSV Eindhoven extended their lead to 10 points in a 2-1 comeback victory over bottom side Sparta Rotterdam.
PEC Zwolle closed the gap on third-placed AZ Alkmaar thanks to a 3-2 win against Heerenveen in Tuesday's only Eredivisie game.
Luuk de Jong scored a hat-trick as PSV Eindhoven moved 10 points clear at the top of the Eredivisie with a 4-0 thrashing of PEC Zwolle.
Youness Mokhtar's early strike clinched PEC Zwolle a 1-0 home win against NAC Breda and kept them in touch with the Eredivisie's top three.
Eredivisie leaders PSV Eindhoven returned to winning ways as they beat 10-man ADO Den Haag 3-0 at the Philips Stadion.
PSV Eindhoven conceded a last-gasp equaliser as FC Groningen fought back to draw 3-3 in the Eredivisie.
PSV Eindhoven cemented their place at the top of the Eredivisie table with a hard-fought 1-0 win over Sparta Rotterdam.
Wins for PEC Zwolle and Feyenoord on Saturday kept both teams in the mix for the Eredivisie's European places.
Heerenveen ended a run of four successive Eredivisie defeats with a 0-0 draw at Sparta Rotterdam on Friday.
Hirving Lozano and Jurgen Locadia each scored twice as PSV Eindhoven restored their five-point lead at the top of the Eredivisie.
Kasper Dolberg scored twice as Ajax beat rivals Feyenoord 4-1 in the Eredivisie on Sunday.
Feyenoord missed the chance to go level on points with Eredivisie leaders PSV after being held to a goalless home draw by PEC Zwolle.
Feyenoord won 4-0 at AZ to climb up to second, Ajax beat Heerenveen by the same scoreline while Vitesse and Utrecht drew 1-1.
Yuki Kobayashi fired a second-half winner as Heerenveen climbed top of the Eredivisie table with a 2-1 victory at Willem II.
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