Granada slumped to a seventh straight defeat under boss Tony Adams, losing 2-1 at home to Espanyol in their final match of the season.
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Osasuna won the battle of the basement clubs, while Jose Gaya's second-half goal gave Valencia a 1-0 away win at Espanyol.
Barcelona leapfrogged Real Madrid to the top of La Liga with a 3-0 win over Espanyol in the Catalan Derby.
Can Barcelona keep their title push on track against local rivals Espanyol? Follow our live updates or watch on Sky Sports 2.
Barcelona boss Luis Enrique has backed the returning Neymar to boost his side's La Liga title hopes ahead of Saturday's derby with Espanyol.
Tony Adams saw his Granada side pushed closer towards relegation, while Atletico Madrid suffered a rare defeat.
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