Tony Adams saw his Granada side pushed closer towards relegation, while Atletico Madrid suffered a rare defeat.
Real Madrid will look to bounce back from their Clasico heartache but face a tricky task in doing so as they travel to Deportivo.
Antoine Griezmann scored his 100th career goal in Spain as Atletico Madrid beat Espanyol 1-0 on Saturday.
Valencia's good form continued as they held high-flying Sevilla to a goalless draw in La Liga.
Diego Simeone will stay with Atletico Madrid, says Guillem Balague in his weekly Q&A and chats Tony Adams, David de Gea and Toni Kroos.
Sevilla were celebrating victory for the first time in over a month after beating Deportivo La Coruna 4-2 in La Liga.
A Filipe Luis goal kept Atletico Madrid's winning run going as they beat Real Sociedad 1-0.
Jose Antonio Reyes fired Espanyol to a late, 2-1 turnaround La Liga victory over Real Betis.
Upgrade now for an unmissable spring
Catch the action - watch instantly from £6.99
Goals, highlights, previews and more...
Check out all the latest transfer news
On the move? Listen to our articles...