A goal late in each half steered Heracles Almelo to three points as they beat NEC Nijmegen 2-0 at the Polman Stadion.
Luuk de Jong capped a 24-minute blitz as PSV stormed back to the top of the Eredivisie with a 4-1 win over NEC in Nijmegen.
Ajax moved a step closer to reclaiming the Eredivisie title on Sunday with a thumping 4-0 win over FC Twente.
Ajax slipped up but still moved back to the top of the Eredivisie table with a 2-2 draw at home to FC Utrecht.
Ajax failed to take advantage of PSV's Saturday slip-up as they dropped their first points in five Eredivisie games at home to NEC.
Defending Eredivisie champions PSV maintained their one point lead at the top of league with a comfortable 3-0 win away at Nijmegen on Sunday.