Monday 22 May 2017 11:28, UK
Billy Vunipola has been forced to withdraw from the upcoming British and Irish Lions tour to New Zealand because of a shoulder injury.
The Saracens No 8 has been managing the injury but it now requires further medical treatment.
Wasps back row James Haskell has been called up as Vunipola's replacement and he will join up with the squad after next week's Aviva Premiership final.
"It is really disappointing for Billy and we know how much he was looking forward to joining the squad," Lions head coach Warren Gatland said.
"He has been carrying an injury and feels he wouldn't be able to contribute fully to the tour and needs further medical treatment.
"We really appreciate his honesty in making this decision and wish him luck with his recovery.
"We have called up James. We wish him all the best next weekend and look forward to welcoming him into our camp before we depart."
Vunipola missed four months of the season with a knee injury but returned to action in March to help England retain their Six Nations crown.
He was man of the match in Saracens' Champions Cup final win over Clermont on May 13 and featured in their Premiership semi-final defeat by Exeter on Saturday.
Former England and Lions player Will Greenwood told Sky Sports News HQ: "For young Billy, it's a huge blow.
"The pinnacle for any northern hemisphere player is to get the opportunity to pull on the red jersey as a Lion.
"It's not only personal disappointment it's collective disappointment as Billy was nominated World Player of the Year last year
"He was also at the heart of Eddie Jones's charge to an 18-match unbeaten run, a Grand Slam, three Tests in Australia.
"The only scalp they didn't get was the All Blacks and Billy was going to get a crack at them and a crack at Kieran Read - the best No 8 in the world.
"It's a huge blow. To lose someone like that is a hammer blow."
Vunipola is the second player to pull out of Gatland's squad after Leicester and England scrum-half Ben Youngs withdrew on compassionate grounds after learning that his sister-in-law was terminally ill.
The British and Irish Lions' 10-match tour of New Zealand, which includes three Tests against the All Blacks, gets underway on June 3.
The 2017 British and Irish Lions tour to New Zealand will be broadcast live on Sky Sports from June 3
